SOX Family Members Expression in Canine Oral Melanoma: Role of the SOX3 in Tumor Aggressiveness

Simple Summary The aggressiveness of oral melanoma may be related to several mutations that occur during development. Based on the knowledge of the role of SOX family transcription factors in other neoplastic types, it is necessary to understand their behavior in oral melanomas. In this study, the expression of SOX2, SOX3 and SOX10 and their relationship with the proliferative index and histological aspects indicative of aggressiveness in canine oral melanomas were evaluated. Thirty tumors were reviewed histologically and the expression of Melan-A, SOX2, SOX3, SOX10 and Ki67 in these tumors was determined. All tumors presented histomorphological characteristics compatible with malignant tumors and immunopositivity for Melan-A. Among the markers analyzed, the relationship between the loss of SOX3 expression in tumors with higher proliferative rates stood out. An inverse correlation was also observed between the expression of cytoplasmic SOX10 and nuclear SOX10, suggesting an alteration in the localization of this protein in oral melanomas. Among the SOX family proteins studied, the SOX3 protein plays an important role in the regulation of cell proliferation in oral melanomas. New studies of this gene transcription pathway may aid in possible prognostic and predictive determinations of the SOX3 protein in canine oral melanoma.

• Publication year

  2025

• Venue

  Veterinary Sciences

• Publication date

  2025-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/vetsci12090851PMID 41012776PMCID 12474294
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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