Glycerol-based soft vesicular systems for nose to brain delivery of 131I-melatonin: Synthesis, Characterization, Biodistribution and Pharmacokinetic investigations

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Journal of Drug Delivery Science and Technology

• Publication date

  2025-09-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/j.jddst.2025.107482
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Nucleus targeting-functionalized cell-membrane nanovesicles for intranasal delivery of therapeutic plasmid DNA into the brain for the treatment of glioblastoma

  2025cited by this paper
• Intranasal Delivery of Kaempferol via Magnesomes for Brain Seizure Treatment: Design, Characterization, and Biodistribution Studies.

  2025cited by this paper
• Glycerosomes: Versatile Carriers for Multi-Route Drug Delivery Systems

  2025cited by this paper
• Intranasal Mucoadhesive In Situ Gel of Glibenclamide-Loaded Bilosomes for Enhanced Therapeutic Drug Delivery to the Brain

  2025cited by this paper
• Chitosan-modified polymeric nanoparticles for the nose-to-brain drug delivery of paroxetine: an in vitro and in vivo evaluation.

  2024cited by this paper
• Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo Distribution

  2024cited by this paper
• Fluidized spanlastics for intranasal brain delivery of lacosamide aiming to control status epilepticus: Design, Characterization, Ex-vivo permeation, Radioiodination and In-vivo biodistribution studies

  2024cited by this paper
• Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study

  2024cited by this paper
• Nanovesicular-Mediated Intranasal Drug Therapy for Neurodegenerative Disease

  2023cited by this paper
• Injectable systems of chitosan in situ forming composite gel incorporating linezolid-loaded biodegradable nanoparticles for long-term treatment of bone infections

  2023cited by this paper
• Exploring the potential of intranasal drug delivery systems in the management of hypertension

  2023cited by this paper
• Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an Antidepressant Drug

  2023cited by this paper
• Preparation and evaluation of radiolabeled gliclazide parenteral nanoemulsion as a new tracer for pancreatic β-cells mass

  2023cited by this paper
• In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose‐to‐brain drug delivery

  2023cited by this paper
• Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

  2022cited by this paper
• Intranasal administration of 99mTc-topiramate-loaded phospholipid magnesome potential route for enhanced brain delivery: Characterization, biodistribution, and pharmacokinetic behaviors

  2022cited by this paper
• Heart Uptake of [18F]Fluoro-4-Thia-Oleate in a Non-Alcoholic Fatty Liver Disease Mouse Model

  2022cited by this paper
• Molecular interactions of hesperidin with DMPC/cholesterol bilayers.

  2022cited by this paper
• Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate

  2022cited by this paper
• Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality

  2022cited by this paper
• Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal

  2022cited by this paper
• Ex vivo permeation parameters and skin deposition of melatonin-loaded microemulsion for treatment of alopecia

  2022cited by this paper
• Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson’s disease: a preliminary evidence

  2022cited by this paper
• Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment

  2022cited by this paper
• Melatonin enhances the low-temperature combined low-light tolerance of pepper (Capsicum annuum L.) seedlings by regulating photosynthesis, carotenoid, and hormone metabolism

  2022cited by this paper
• Improved stability and skin penetration through glycethosomes loaded with glycyrrhetinic acid

  2022cited by this paper
• Glycerosomes: A Novel Vesicular Drug Delivery System

  2022cited by this paper
• Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

  2022cited by this paper
• Intranasal Niosomal in situ Gel as a Novel Strategy for Improving Citicoline Efficacy and Brain Delivery in Treatment of Epilepsy: In vitro and ex vivo characterization and in vivo pharmacodynamics investigation.

  2022cited by this paper
• Preparation, Characterization, and In vivo Biodistribution Study of Intranasal 131I-Clonazepam-Loaded Phospholipid Magnesome as a Promising Brain Delivery System: Biodistribution and pharmacokinetic behavior of intranasal 131I-Clonazepam loaded phospholipid magnesome as a potential brain targeting s

  2021cited by this paper
• Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery

  2021cited by this paper
• Comparative evaluation of intranasally delivered quetiapine loaded mucoadhesive microemulsion and polymeric nanoparticles for brain targeting: pharmacokinetic and gamma scintigraphy studies

  2021cited by this paper
• Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy

  2021cited by this paper
• Challenges in the diagnosis of Parkinson's disease.

  2021cited by this paper
• Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection

  2021cited by this paper
• Multivesicular Vesicles: Preparation and Applications

  2021cited by this paper
• Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.

  2021cited by this paper
• Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m

  2021cited by this paper
• Nasal Spray Formulations Based on Combined Hyalurosomes and Glycerosomes Loading Zingiber officinalis Extract as Green and Natural Strategy for the Treatment of Rhinitis and Rhinosinusitis

  2021cited by this paper
• Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections.

  2021cited by this paper
• Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets

  2021cited by this paper
• Effect of Melatonin Administration on Mitochondrial Activity and Oxidative Stress Markers in Patients with Parkinson's Disease

  2021cited by this paper
• Evaluating the synergistic effect of Mucuna prurines extract and sesame oil against the Parkinson’s disease zebrafish model: in-vivo/in-silico approach

  2021cited by this paper
• Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery

  2021cited by this paper
• Melatonin as first‐line treatment for sleep disorders in Parkinson's disease?

  2021cited by this paper
• Drug release study of the chitosan-based nanoparticles

  2021cited by this paper
• Formulation, characterization and evaluation of in vitro antioxidant potential of melatonin and quercetin loaded liposomes

  2021cited by this paper
• Investigating the potential of utilizing glycerosomes as a novel vesicular platform for enhancing intranasal delivery of lacidipine.

  2020cited by this paper
• Glycerosome of Melissa officinalis L. Essential Oil for Effective Anti-HSV Type 1

  2020cited by this paper
• Ethanol injection technique for liposomes formulation: An insight into development, influencing factors, challenges and applications

  2020cited by this paper
• Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer's disease.

  2020cited by this paper
• Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations

  2020cited by this paper
• Fabrication and characterization of sterically stabilized liposomes of topotecan

  2020cited by this paper
• Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken Design.

  2020cited by this paper
• Chitosan-Based Nanocarriers for Nose to Brain Delivery

  2019cited by this paper
• Lipid-Based Nanocarriers for Lymphatic Transportation

  2019cited by this paper
• Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation

  2019cited by this paper
• Nose to Brain Delivery of Galantamine Loaded Nanoparticles: In-vivo Pharmacodynamic and Biochemical Study in Mice.

  2018cited by this paper
• Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box–Behnken statistical design

  2018cited by this paper
• Melatonin vitamin C‐based nanovesicles for treatment of androgenic alopecia: Design, characterization and clinical appraisal

  2018cited by this paper
• Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

  2018cited by this paper
• Effect of polysorbate 80 on the intranasal absorption and brain distribution of tetramethylpyrazine phosphate in rats

  2018cited by this paper
• Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

  2017cited by this paper
• Sertaconazole nitrate loaded nanovesicular systems for targeting skin fungal infection: In-vitro, ex-vivo and in-vivo evaluation.

  2017cited by this paper
• Role of butter oil in brain targeted delivery of Quetiapine fumarate microemulsion via intranasal route

  2017cited by this paper
• The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches

  2017cited by this paper
• Glycerosomes: Investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances.

  2017cited by this paper
• Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration.

  2016cited by this paper
• Liposomal delivery systems for intestinal lymphatic drug transport

  2016cited by this paper
• Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs.

  2016cited by this paper
• Influence of cholesterol on liposome stability and on in vitro drug release

  2015cited by this paper
• Ashtang Ghrita: A noble Ayurveda drug for Central Nervous System

  2015cited by this paper
• Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles.

  2014cited by this paper
• Insights into direct nose to brain delivery: current status and future perspective

  2014cited by this paper
• Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation

  2014cited by this paper
• Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs.

  2013cited by this paper
• Glycerosomes: a new tool for effective dermal and transdermal drug delivery.

  2013cited by this paper
• Cellular fusion and whitening effect of a chitosan derivative coated liposome.

  2012cited by this paper
• Intranasal drug delivery: an efficient and non-invasive route for systemic administration: focus on opioids.

  2012cited by this paper
• Brain delivery of olanzapine by intranasal administration of transfersomal vesicles

  2012cited by this paper
• Lecithin/chitosan nanoparticles for transdermal delivery of melatonin

  2011cited by this paper
• Celecoxib-loaded liposomes: effect of cholesterol on encapsulation and in vitro release characteristics.

  2010cited by this paper
• Single bilayer liposomes prepared without sonication.

  1973cited by this paper

• PEGylated flexosomes as a novel intranasal carrier for quetiapine: formulation, characterization, and in vivo studies.

  2026cites this paper