The PI3K/Akt and MAPK-ERK1/2 pathways are altered in STZ induced diabetic rat placentas.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Histology and Histopathology

• Publication date

  2014-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.14670/HH-29.743PMID 24346807
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Over-expression of a putative poplar glycosyltransferase gene, PtGT1, in tobacco increases lignin content and causes early flowering

  2012cited by this paper
• Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes.

  2011cited by this paper
• Maternal diabetes affects cell proliferation in developing rat placenta.

  2011cited by this paper
• The expression of Akt and ERK1/2 proteins decreased in dexamethasone-induced intrauterine growth restricted rat placental development

  2011cited by this paper
• Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy

  2011cited by this paper
• Expression of glucocorticoid receptor and glucose transporter-1 during placental development in the diabetic rat.

  2011cited by this paper
• High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway

  2010cited by this paper
• AKT Controls Human First Trimester Trophoblast Cell Sensitivity to FAS-Mediated Apoptosis by Regulating XIAP Expression1

  2010cited by this paper
• IL‐6 and high glucose synergistically upregulate MMP‐1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c‐Jun

  2010cited by this paper
• MMP/ TIMP balance is modulated in vitro by 15dPGJ2 in fetuses and placentas from diabetic rats

  2009cited by this paper
• Insulin and the IGF system in the human placenta of normal and diabetic pregnancies

  2009cited by this paper
• High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway.

  2009cited by this paper
• Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling.

  2008cited by this paper
• PI3K/PTEN signaling in tumorigenesis and angiogenesis.

  2008cited by this paper
• The IGF Axis and Placental Function

  2008cited by this paper
• Is there a relationship between PCNA expression and diabetic placental development during pregnancy?

  2008cited by this paper
• High glucose promotes the production of collagen types I and III by cardiac fibroblasts through a pathway dependent on extracellular-signal-regulated kinase 1/2

  2007cited by this paper
• Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1/2.

  2007cited by this paper
• Antenatal dexamethasone treatment leads to changes in gene expression in a murine late placenta.

  2007cited by this paper
• Streptozotocin-induced diabetes decreases placenta growth factor (PlGF) levels in rat placenta.

  2007cited by this paper
• Akt1 in Endothelial Cell and Angiogenesis

  2006cited by this paper
• Interstitial trophoblast invasion in the decidua and mesometrial triangle during the last third of pregnancy in the rat.

  2006cited by this paper
• Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins.

  2006cited by this paper
• Phosphatidylinositol 3-Kinase Activity Is Critical for Glucose Metabolism and Embryo Survival in Murine Blastocysts*

  2006cited by this paper
• Phosphoinositide 3‐kinase controls early and late events in mammalian cell division

  2006cited by this paper
• Diverse physiological functions for dual-specificity MAP kinase phosphatases

  2006cited by this paper
• Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis

  2006cited by this paper
• Glucose utilization and the PI3-K pathway: mechanisms for cell survival in preimplantation embryos.

  2006cited by this paper
• Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats

  2005cited by this paper
• Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy

  2005cited by this paper
• Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling.

  2005cited by this paper
• ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta

  2005cited by this paper
• Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes

  2005cited by this paper
• Signalling pathways regulating the invasive differentiation of human trophoblasts: a review.

  2005cited by this paper
• Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction.

  2005cited by this paper
• The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo.

  2005cited by this paper
• Development of structures and transport functions in the mouse placenta.

  2005cited by this paper
• Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications.

  2005cited by this paper
• The Akt pathway: molecular targets for anti-cancer drug development.

  2004cited by this paper
• Erk2 Signaling and Early Embryo Stem Cell Self-Renewal

  2004cited by this paper
• Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2.

  2004cited by this paper
• Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts.

  2004cited by this paper
• 'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors.

  2003cited by this paper
• Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

  2003cited by this paper
• Protein kinase B alpha/Akt1 regulates placental development and fetal growth.

  2003cited by this paper
• An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development

  2003cited by this paper
• Expression of insulin, insulin-like growth factor I and glucocorticoid receptor in rat uterus and embryo during decidualization, implantation and organogenesis.

  2003cited by this paper
• Essential role for ERK2 mitogen‐activated protein kinase in placental development

  2003cited by this paper
• Fetoplacental angiogenesis during gestation is biphasic, longitudinal and occurs by proliferation and remodelling of vascular endothelial cells.

  2002cited by this paper
• Regulation and targets of receptor tyrosine kinases.

  2002cited by this paper
• Akt: versatile mediator of cell survival and beyond.

  2002cited by this paper
• The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells.

  2002cited by this paper
• Placental development: Lessons from mouse mutants

  2001cited by this paper
• Protein kinase B (PKB/Akt) – a key regulator of glucose transport?

  2001cited by this paper
• Embryonic lethality and fetal liver apoptosis in mice lacking the c‐raf‐1 gene

  2001cited by this paper
• Genes governing placental development.

  2001cited by this paper
• Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women.

  2001cited by this paper
• Growth characteristics of diabetic rat ectoplacental cones in vivo and in vitro

  2000cited by this paper
• The Sos1 and Sos2 Ras‐specific exchange factors: differences in placental expression and signaling properties

  2000cited by this paper
• Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

  2000cited by this paper
• Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.

  1999cited by this paper
• Location of insulin receptors in the placenta and its progenitor tissues

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Insulin receptors in syncytitrophoblast and fetal endothelium of human placenta. Immunohistochemical evidence for developmental changes in distribution pattern

  1994cited by this paper
• Maternal Diabetes in Rats: I. Effects on Placental Growth and Protein Turnover

  1988cited by this paper
• Early growth retardation in diabetic pregnancy.

  1979cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Promotes Hyperglycemia and Susceptibility to Streptozotocin-Induced Diabetes in Female Mice In Vivo

  2025cites this paper
• Hyperglycemia disturbs trophoblast functions and subsequently leads to failure of uterine spiral artery remodeling

  2023cites this paper
• Myo‐inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism

  2023cites this paper
• Deep Insight of the Pathophysiology of Gestational Diabetes Mellitus

  2022cites this paper
• Effects of glucose and osmotic pressure on the proliferation and cell cycle of human chorionic trophoblast cells

  2022cites this paper
• Maternal Diabetes Impairs Insulin and IGF-1 Receptor Expression and Signaling in Human Placenta

  2021cites this paper
• Acute glucose fluctuation promotes in vitro intestinal epithelial cell apoptosis and inflammation via the NOX4/ROS/JAK/STAT3 signaling pathway

  2021cites this paper
• The effect of adiponectin and its receptors in placental development of diabetic rats

  2021cites this paper
• MiRNA profiling of plasma-derived exosomes from dairy cows during gestation.

  2019cites this paper
• Streptozotocin-Induced Autophagy Reduces Intracellular Insulin in Insulinoma INS-1E Cells

  2018cites this paper
• Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

  2017cites this paper
• Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus

  2017cites this paper
• Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan

  2016cites this paper
• Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus

  2016cites this paper
• Understanding placental function in pregnancies complicated by Diabetes mellitus: a systems biology approach

  2016cites this paper
• Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics.

  2016cites this paper
• Pyrroloquinoline quinone (PQQ) has potential to ameliorate streptozotocin-induced diabetes mellitus and oxidative stress in mice: A histopathological and biochemical study.

  2015cites this paper
• Pyrroloquinoline quinone ameliorates oxidative stress and lipid peroxidation in the brain of streptozotocin-induced diabetic mice.

  2015cites this paper
• Glucocorticoid exposure altered angiogenic factor expression via Akt/mTOR pathway in rat placenta.

  2015cites this paper
• Enhanced proliferation in colorectal epithelium of patients with type 2 diabetes correlates with β-catenin accumulation.

  2014cites this paper