MAGIS syndrome: Phenotypes, pathogenesis, and treatment

The inherited syndromic immunodysregulatory disorder MAGIS demonstrates the central role of Gαi2 regulation of chemotaxis in humans and a novel pathway by which G proteins regulate T cell activation. Here, the authors review MAGIS clinical features, current genetic and biochemical understanding, and future therapeutic considerations.

• Publication year

  2025

• Venue

  Journal of human immunity

• Publication date

  2025-08-14

• Fields of study

  Medicine

• Identifiers
  DOI 10.70962/jhi.20250065PMID 40926810PMCID 12416919
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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