Ethical and legal considerations of digital animal models: pioneering reduction and replacement.

F. Germani,Julian W. März,Alessandro Luciani,O. Devuyst,Nikola Biller-Andorno

Published 2025 in Trends in Biotechnology

ABSTRACT

The development of digital animal models represents a promising avenue for advancing the ethical principles of reduction and replacement in biomedical research. This paper discusses the potential of models built upon artificial intelligence (AI)-generated synthetic datasets simulating the characteristics and behaviors of model organisms, reducing reliance on live animals in research.

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