Efficacy and Safety of GLP‐1 and Dual GIP/GLP‐1 Receptor Agonists in Idiopathic Intracranial Hypertension: A Systematic Review and Meta‐Analysis

Maria-Ioanna Stefanou,I. Chatziralli,Vaia Lambadiari,Annerose Mengel,Aikaterini Foska,M. Chondrogianni,E. Bakola,Panagiota-Eleni Tsalouchidou,D. Mitsikostas,Gerasimos I. Siasos,U. Ziemann,G. Tsivgoulis

Published 2025 in European Journal of Neurology

ABSTRACT

Repurposing glucagon‐like peptide‐1 (GLP‐1) and GIP/GLP‐1 receptor agonists (RAs) for idiopathic intracranial hypertension (IIH) represents an attractive alternative to current treatments, supported by evidence of potent metabolic effects and reductions in cerebrospinal fluid secretion and intracranial pressure in vivo.

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