Examination of brain morphology and perinatal background factors associated with characteristics of early infantile spontaneous movements.

AIM To clarify the association between characteristics of early infantile general movements (GMs) and clinical background factors, including brain morphological characteristics, in very-low-birth-weight infants (VLBWIs). METHODS GMs were scored using the motor optimality score revised (MOS-R) at a post-term age of 9-20 weeks. The MOS-R is composed of the following five subscales: quality of fidgety movements (Quality FMs), movement patterns (MP), age-adequate movement repertoire (AMR), postural patterns (PP), and movement character (MC). Brain magnetic resonance imaging (MRI) at term-equivalent age was scored using a validated scoring system (MRI score). Factors affecting the MOS-R were investigated using a multiple regression analysis. SUBJECTS Ninety-five VLBWIs managed at Oita University Hospital in 2012-2023, who underwent brain MRI and GMs assessment, were included. The median gestational age at birth and birth weight were 28 weeks, 6 days and 997 g, respectively. RESULTS The multiple regression analysis revealed that MRI score, patent ductus arteriosus (PDA) drug therapy, and sex were associated with MOS-R. In an analysis using the MOS-R subscales as dependent variables, Quality FMs were associated with MRI score and sex; MP was associated with MRI score; AMR was associated with PDA drug therapy, sex, and postnatal steroid use; PP was associated with height at the estimated date of confinement (EDC); and MC was associated with PDA drug therapy and body weight at EDC. CONCLUSION MOS-R is associated with brain morphological development. Its subscales are influenced by different clinical factors.

• Publication year

  2025

• Venue

  Brain & development (Tokyo. 1979)

• Publication date

  2025-09-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.braindev.2025.104433PMID 40939503
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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