8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Genes & Diseases

• Publication date

  2025-09-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/j.gendis.2025.101874
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• ADAR1p110 promotes hepatocellular carcinoma metastasis via the miR-451a/TUBA1A axis

  2025cited by this paper
• Silencing LINC01547 induces hepatocellular carcinoma cell apoptosis and metastasis inhibition via the ADAR1/FAK and miR-146b-5p/RAC1 axes

  2025cited by this paper
• Clinical Impact of Cellular Senescence and RNA Dysregulation in HCC Is Associated With MASLD and HCV-SVR

  2025cited by this paper
• 8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia

  2024cited by this paper
• Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

  2024cited by this paper
• Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications

  2024cited by this paper
• The role of ADAR1 through and beyond its editing activity in cancer

  2024cited by this paper
• Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway

  2024cited by this paper
• Structural perspectives on adenosine to inosine RNA editing by ADARs

  2024cited by this paper
• ADAR1: from basic mechanisms to inhibitors

  2024cited by this paper
• Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma

  2023cited by this paper
• 8-Chloroadenosine Induces ER Stress and Apoptotic Cell Death in Cholangiocarcinoma Cells

  2023cited by this paper
• Roles of peroxisome proliferator‐activated receptors in hepatocellular carcinoma

  2023cited by this paper
• Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.

  2023cited by this paper
• Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC

  2023cited by this paper
• Isoform-specific functions of PPARγ in gene regulation and metabolism

  2022cited by this paper
• ADAR1 and its implications in cancer development and treatment.

  2022cited by this paper
• ADAR1 inhibits adipogenesis and obesity by interacting with dicer to promote the maturation of miR-155-5P.

  2022cited by this paper
• Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine

  2021cited by this paper
• Global, regional and national burden of primary liver cancer by subtype.

  2021cited by this paper
• Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado

  2021cited by this paper
• The cancer metabolic reprogramming and immune response

  2021cited by this paper
• ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity

  2020cited by this paper
• Therapeutic potential of PPARγ natural agonists in liver diseases

  2020cited by this paper
• The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.

  2020cited by this paper
• The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer

  2020cited by this paper
• Global Burden of 5 Major Types Of Gastrointestinal Cancer.

  2020cited by this paper
• Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

  2020cited by this paper
• The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses.

  2020cited by this paper
• 8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway

  2020cited by this paper
• The Role of PPARs in Disease

  2020cited by this paper
• 8‐chloro‐adenosine activity in FLT3‐ITD acute myeloid leukemia

  2019cited by this paper
• ATP citrate lyase: a central metabolic enzyme in cancer.

  2019cited by this paper
• ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

  2019cited by this paper
• lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma

  2018cited by this paper
• AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer.

  2018cited by this paper
• Metabolic features of cancer stem cells: the emerging role of lipid metabolism

  2018cited by this paper
• Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis

  2018cited by this paper
• Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

  2017cited by this paper
• Amplification of Adipogenic Commitment by VSTM2A

  2017cited by this paper
• ADAR1 overexpression is associated with cervical cancer progression and angiogenesis

  2017cited by this paper
• ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

  2016cited by this paper
• ATP citrate lyase (ACLY): a promising target for cancer prevention and treatment.

  2015cited by this paper
• Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.

  2015cited by this paper
• Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

  2015cited by this paper
• 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition

  2015cited by this paper
• Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.

  2014cited by this paper
• A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma

  2013cited by this paper
• Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

  2013cited by this paper
• ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia

  2012cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• ATP Analog Enhances the Actions of a Heat Shock Protein 90 Inhibitor in Multiple Myeloma Cells

  2011cited by this paper
• A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels

  2010cited by this paper
• Inhibition of ATP synthase by chlorinated adenosine analogue.

  2009cited by this paper
• Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

  2007cited by this paper
• Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

  1996cited by this paper
• Magnesium and Phosphorous: The Electrolytes of Energy Metabolism

  1985cited by this paper

• No citing papers are available for this paper.