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Exploring Medicinal Plants as Natural Inhibitors of Collagenase, Elastase, and Hyaluronidase: A Novel Approach for Cosmeceutical Innovation

R. D. Tak,A. Patil,B. Jaiwal,Y. P. Kale

Published 2025 in Biomedical & Pharmacology Journal

ABSTRACT

The market value of natural cosmetics continues to rise due to their reduced side effects, resulting in their increasing amalgamation into cosmetic formulations. Plant-derived materials are a rich source of bioactive compounds that can serve as anti-aging and anti-wrinkle agents, as well as therapeutic agents for various dermatological conditions. In this study, 140 medicinal plant materials were collected, taxonomically authenticated, and subjected to ethanolic extraction. The resulting extracts were screened for their inhibitory activity against Clostridium histolyticum collagenase (ChC), Porcin pancreatic elastase (PpE), and Bovine testes hyaluronidase (BtH) for identifying potential anti-aging agents suitable for cosmetic applications. The highest total phenolic content (TPC) (31.95 ± 0.045 mg/ml) was observed in Terminalia arjuna bark. Overall, 71, 42, and 59 plant extracts exhibited anti-ChC, anti-PpE, and anti-BtH activities, respectively. Among all inhibitory activity exhibiting plants, Terminalia arjuna bark exhibited the highest inhibitory activity against ChC, PpE (99.95 ± 1.3% and 99.98 ± 1.5% at 100 µg/ml TPC), and BtH (98.80 ± 2.4% at 150 µg/ml TPC). Woodfordia fructicosa flower, Peltophorum pterocarpum leaf, and Bergenia ligulata root exhibited maximum inhibitory potential against aging enzymes. The inhibitory activities of plant extracts were found to be dependent upon the concentration of TPC. A one-way ANOVA test revealed plant extracts exhibit significant inhibitory potential (p<0.05) against aging enzymes. The findings indicate that medicinal plants exhibiting effective inhibitors of collagenase, elastase, and hyaluronidase could be useful for application in cosmetic formulations.

PUBLICATION RECORD

  • Publication year

    2025

  • Venue

    Biomedical & Pharmacology Journal

  • Publication date

    2025-09-30

  • Fields of study

    Not labeled

  • Identifiers
    DOI 10.13005/bpj/3242
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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