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Antibiotic resistome, potential pathogenic bacteria and associated health risk in geogenic chromium groundwater.

Xiaolin Zhou,Bingying Gao,Huiling Cui,Fu-Yi Huang,Christopher Rensing,Yi Zhao,Huaming Guo

Published 2025 in Environmental Research

ABSTRACT

Geogenic chromium (Cr) contamination in groundwater poses a global environmental challenge. However, with antibiotic resistance remaining a public health threat, the occurrence and associated health risks of antibiotic resistomes in Cr contaminated groundwater and their linkages to geogenic Cr are poorly understood. Here, we assessed the groundwater microbiome, potential pathogenic bacteria, and antibiotic resistomes with associated health risks in geogenic Cr impacted groundwater across shallow (< 100 m) and deep (> 100 m) aquifers in a plateau from Northwestern China. A total of 174 antibiotic resistance genes (ARGs) were detected with absolute abundances reaching 1.28×108 copies/L. Shallow and deep groundwater harbored distinct ARG profiles with significantly higher abundance and associated health risks presented in shallow groundwater (p < 0.01). A total of 332 potential pathogenic bacteria were identified, abundances of which 53.9% were strongly correlated to the prevalent ARGs. Toxic Cr(VI) as a potential co-selective agent was positively associated with elevated ARG-linked potential pathogenic bacteria and mobile genetic elements (MGEs). Our findings collectively revealed the geogenic Cr contaminated groundwater as a significant reservoir of ARGs and potential pathogens, highlighting the dual risks of geogenic Cr as both a toxicant and promoter for accelerating ARGs within aquifers.

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