Forever Chemicals: An Exploratory, Population‐Based Analysis of Per‐ and Polyfluoroalkyl Substances Exposure and Effects on Sinonasal Health

Per‐ and Polyfluoroalkyl Substances (PFAS) are widely used chemicals, notably in nonstick coatings, fire‐fighting foams and equipment, and surfactants. These chemicals degrade slowly and accumulate in tissues and the environment, being detected in water, air, wildlife, and soil across the world. Initial studies have shown that these chemicals are associated with harmful health effects, but research in this area remains limited, especially in sinonasal diseases.

• Publication year

  2025

• Venue

  Allergy. European Journal of Allergy and Clinical Immunology

• Publication date

  2025-10-10

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1111/all.70092PMID 41070772
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
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