Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  European journal of medicinal chemistry

• Publication date

  2011-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejmech.2011.01.007PMID 21281992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.

  2008cited by this paper
• Synthesis, Structure and Hypoxic Cytotoxicity of 3‐Amino‐1,2,4‐benzotriazine‐1,4‐dioxide Derivatives

  2007cited by this paper
• Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.

  2007cited by this paper
• Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.

  2007cited by this paper
• Development of hypoxia selective cytotoxins for cancer treatment: an update.

  2006cited by this paper
• Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02.

  2006cited by this paper
• Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.

  2006cited by this paper
• Mature results from a randomized Phase II trial of cisplatin plus 5‐fluorouracil and radiotherapy with or without tirapazamine in patients with resectable Stage IV head and neck squamous cell carcinomas

  2006cited by this paper
• Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial.

  2006cited by this paper
• Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02).

  2005cited by this paper
• Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures.

  2005cited by this paper
• Tirapazamine Cytotoxicity for Neuroblastoma Is p53 Dependent

  2005cited by this paper
• Exploiting tumour hypoxia in cancer treatment

  2004cited by this paper
• The hypoxic tumour microenvironment and metastatic progression

  2004cited by this paper
• Acute Hypoxia Enhances Spontaneous Lymph Node Metastasis in an Orthotopic Murine Model of Human Cervical Carcinoma

  2004cited by this paper
• Chris Lipinski discusses life and chemistry after the Rule of Five.

  2003cited by this paper
• Chris Lipinski discusses life and chemistry after the Rule of Five.

  2003cited by this paper
• Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.

  2003cited by this paper
• Hypoxia — a key regulatory factor in tumour growth

  2002cited by this paper
• Microenvironment-induced cancer metastasis

  2000cited by this paper
• Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia

  2000cited by this paper
• Bioreductive drugs into the next millennium.

  1998cited by this paper
• Oxygenation predicts radiation response and survival in patients with cervix cancer.

  1998cited by this paper
• Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck.

  1996cited by this paper
• Hypoxia-Specific Cytotoxins in Cancer Therapy.

  1996cited by this paper
• The influence of microenvironmental factors during cancer therapy.

  1994cited by this paper
• The influence of microenvironmental factors during cancer therapy.

  1994cited by this paper
• SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.

  1993cited by this paper
• Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation.

  1992cited by this paper
• Estimation of High Pressure Liquid Chromatographic Retention Indices of Narcotic Analgetics and Related Drugs

  1980cited by this paper
• Estimation of high pressure liquid chromatographic retention indices of narcotic analgetics and related drugs.

  1979cited by this paper

• Facile synthesis of benzo[e][1,2,4]triazepin-5-ones through a base medicated [4+3] cycloaddition

  2025cites this paper
• 3-Substituted Blatter Radicals: Cyclization of N-Arylguanidines and N-Arylamidines to Benzo[e][1,2,4]triazines and PhLi Addition

  2023cites this paper
• Quinoxaline 1,4-di-N-oxides: a review of the importance of their structure in the development of drugs against infectious diseases and cancer

  2021cites this paper
• Tandem synthesis of highly functionalized 1,2,3-benzotriazines from isocyanides, aniline and dialkyl azadicarboxylate via Cu-catalyzed intramolecular C H activation reactions

  2020cites this paper
• Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs.

  2019cites this paper
• 3-Substituted Benzo[ e][1,2,4]triazines: Synthesis and Electronic Effects of the C(3) Substituent.

  2019cites this paper
• Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia

  2019cites this paper
• The Diversity of Heterocyclic N-oxide Molecules: Highlights on their Potential in Organic Synthesis, Catalysis and Drug Applications

  2019cites this paper
• An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds.

  2017cites this paper
• Novel potent HIF-1 inhibitors for the prevention of tumor metastasis: discovery and optimization of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives

  2015cites this paper
• Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents.

  2015cites this paper
• Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.

  2014cites this paper
• Synthesis, Preferentially Hypoxic Apoptosis and Anti-Angiogenic Activity of 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide Bearing Alkyl Linkers with a 3-Amino-1,2,4-Benzotriazine-1-Oxide Moiety

  2014cites this paper
• The anticancer drug tirapazamine has antimicrobial activity against Escherichia coli, Staphylococcus aureus and Clostridium difficile.

  2013cites this paper
• Head and neck cancer: from anatomy to biology

  2013cites this paper
• Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH3CN complex

  2012cites this paper
• Synthesis of cinnoline 1-oxides by the reaction of ortho-fluoronitrobenzenes with enediamines

  2012cites this paper
• Synthesis and Biological Evaluation of 3-Aryl-quinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives as Hypoxic Selective Anti-tumor Agents

  2012cites this paper
• DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.

  2012cites this paper
• Synthesis, Hypoxia‐Selective Cytotoxicity of New 3‐Amino‐1,2,4‐benzotriazine‐1,4‐dioxide Derivatives.

  2011cites this paper