Thiadiazole as a Promising Fragment to Discover Novel Agrochemicals: A Review.

Thiadiazole is a five-membered heterocyclic compound that contains sulfur (S) and nitrogen (N) atoms. The substance has a unique structure and diverse properties. This structural feature is indicative of a wide range of biological activities exhibited by thiadiazole derivatives, thus positioning them as key players in the domain of pesticide research and development. The development of highly effective pesticides is contingent upon a profound comprehension of the physical properties and precise analysis of their structure-activity relationships (SAR). To this end, this perspective provides a systematic review of the two main isomeric derivatives of thiadiazole (1,3,4-thiadiazole and 1,2,3-thiadiazole) in terms of their antibacterial, antifungal, insecticidal, antiviral, herbicidal, and plant growth regulatory properties from 2014 to 2025. It is hypothesized that this review will provide a new theoretical basis and innovative perspective for discovering and evaluating effective thiadiazole pesticides and elucidating their mechanisms of action.

• Publication year

  2025

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2025-10-15

• Fields of study

  Agricultural and Food Sciences, Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.jafc.5c06147PMID 41092245
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thioether Oxidation Chemistry in Reactive Oxygen Species (ROS)-Sensitive Trigger Design: A Kinetic Analysis

  2025cited by this paper
• Design, synthesis, and antimicrobial evaluation of novel 1,2,4-trizaole thioether derivatives with a 1,3,4-thiadiazole skeleton

  2025cited by this paper
• Synthesis and Antifungal Activity Evaluation of Novel L-Carvone-Based 1,3,4-Thiadiazole-amide Derivatives as a Potential Succinate Dehydrogenase Inhibitor.

  2024cited by this paper
• New chalcone derivatives containing morpholine-thiadiazole: Design, synthesis and evaluation of against tobacco mosaic virus.

  2024cited by this paper
• The Role of (E)-β-Farnesene in Tritrophic Interactions: Biosynthesis, Chemoreception, and Evolution.

  2024cited by this paper
• Design, Synthesis, Antifungal Evaluation, and Three-Dimensional Quantitative Structure-Activity Relationship of Novel 5-Sulfonyl-1,3,4-thiadiazole Flavonoids.

  2024cited by this paper
• Advancing drug discovery: Thiadiazole derivatives as multifaceted agents in medicinal chemistry and pharmacology.

  2024cited by this paper
• Design, Synthesis, and Herbicidal Activity of Novel Tetrahydrophthalimide Derivatives Containing Oxadiazole/Thiadiazole Moieties.

  2024cited by this paper
• Synthesis and Antifungal Activity of Chalcone Derivatives Containing 1,3,4‐Thiadiazole

  2024cited by this paper
• Synthesis of 5-(Aryl)amino-1,2,3-triazole-containing 2,1,3-Benzothiadiazoles via Azide–Nitrile Cycloaddition Followed by Buchwald–Hartwig Reaction

  2024cited by this paper
• Thiadiazole/Thiadiazine Derivatives as Insecticidal Agent: Design, Synthesis, and Biological Assessment of 1,3,4-(Thiadiazine/Thiadiazole)-Benzenesulfonamide Derivatives as IGRs Analogues against Spodoptera littoralis.

  2024cited by this paper
• Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole.

  2024cited by this paper
• A Review on Recent Progress in Synthesis and Biological Activities of Thiadiazole and its Derivatives

  2024cited by this paper
• Synthesis, characterization, antiviral and antifungal activities of aromatic acyl hydrazono dithiocarbonates

  2024cited by this paper
• Design, synthesis, biological and computational screening of novel pyridine-based thiadiazole derivatives as prospective anti-inflammatory agents

  2024cited by this paper
• Novel Flavonol Derivatives Containing 1,3,4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation

  2024cited by this paper
• Novel 5-Sulfonyl-1,3,4-thiadiazole-Substituted Flavonoids as Potential Bactericides and Fungicides: Design, Synthesis, Three-Dimensional Quantitative Structure-Activity Relationship Studies.

  2024cited by this paper
• Design, Synthesis, Antibacterial, and Antifungal Evaluation of Phenylthiazole Derivatives Containing a 1,3,4-Thiadiazole Thione Moiety

  2024cited by this paper
• Sulfonate derivatives bearing an amide unit: design, synthesis and biological activity studies

  2024cited by this paper
• Antibacterial and antifungal pyrazoles based on different construction strategies.

  2024cited by this paper
• Exploration of Fungicidal Activity and Mode of Action of Ferimzone Analogs.

  2023cited by this paper
• Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity.

  2023cited by this paper
• Green synthesis, biological and molecular docking of some novel sulfonamide thiadiazole derivatives as potential insecticidal against Spodoptera littoralis

  2023cited by this paper
• CoMFA Directed Molecular Design for Significantly Improving Fungicidal Activity of Novel [1,2,4]-Triazolo-[3,4-b][1,3,4]-thiadizoles.

  2023cited by this paper
• Thiazole Ring- The Antimicrobial, Anti-Inflammatory, and Anticancer Active Scaffold

  2023cited by this paper
• Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives

  2023cited by this paper
• Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity

  2023cited by this paper
• Novel 1,3,4-Thiadiazole Derivatives: Synthesis, Antiviral Bioassay and Regulation the Photosynthetic Pathway of Tobacco against TMV Infection

  2023cited by this paper
• Design, Synthesis and Biological Activity of Myricetin Derivatives Containing 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole

  2023cited by this paper
• In vitro/vivo antifungal activity study of novel mandelic acid derivatives as potential fungicides against Thanatephorus cucumeris

  2023cited by this paper
• Discovery, Mode of Action, Resistance Mechanisms, and Plan of Action for Sustainable Use of Group 14 Herbicides

  2023cited by this paper
• Synthesis, antifungal activity and mechanism of action of novel chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole

  2023cited by this paper
• Synthesis, Fungicidal Activity and Plant Protective Properties of 1,2,3-Thiadiazole and Isothiazole-Based N-acyl-N-arylalaninates

  2023cited by this paper
• Research Advances on Matrine

  2022cited by this paper
• Synthesis, Antifungal Activity and Molecular Docking Study of 1,3,4-Thiadiazole-Urea Compounds Containing gem-Dimethylcyclopropane Ring Structure

  2022cited by this paper
• CADD, AI and ML in Drug Discovery: A Comprehensive Review.

  2022cited by this paper
• Synthesis of Novel Indole Schiff Base Compounds and Their Antifungal Activities

  2022cited by this paper
• Synthesis and biological evaluation of new 1,3,4-thiadiazole derivatives as potent antimicrobial agents

  2022cited by this paper
• Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity

  2022cited by this paper
• Solvent-Free Synthesis, In Vitro and In Silico Studies of Novel Potential 1,3,4-Thiadiazole-Based Molecules against Microbial Pathogens

  2022cited by this paper
• Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore.

  2021cited by this paper
• Synthesis, Antifungal Activity, and 3D-QSAR Study of Novel Nopol-Derived 1,3,4-Thiadiazole-Thiourea Compounds

  2021cited by this paper
• Pine Rosin as a Valuable Natural Resource in the Synthesis of Fungicide Candidates for Controlling Fusarium oxysporum on Cucumber.

  2021cited by this paper
• Synthesis, antifungal activity and 3D-QSAR study of novel nopol-based 1,3,4-thiadiazole–thioether compounds

  2021cited by this paper
• Volatile phenolics: A comprehensive review of the anti-infective properties of an important class of essential oil constituents.

  2021cited by this paper
• Design, synthesis and insecticidal activity of new 1,3,4-thiadiazole and 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives under solvent-free conditions

  2021cited by this paper
• New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation

  2021cited by this paper
• Selective hydrogenation catalyst, preparation method and application thereof

  2021cited by this paper
• Synthesis of 1,2,3-Thiadiazole- and Isothiazole-Based Phenyl Substituted Pyridine Containing Carboxamides as Potent Plant Elicitors.

  2021cited by this paper
• Thiazolidinone: A Structural Motif of Great Synthetic and Biological Importance

  2021cited by this paper
• Synthesis and structure–activity relationship of L‐methionine‐coupled 1,3,4‐thiadiazole derivatives with activity against influenza virus

  2021cited by this paper
• Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests.

  2021cited by this paper
• Application of natural products as insecticide candidates: Semisynthesis and biological evaluation of some novel osthole-based esters.

  2020cited by this paper
• Design and development of 1,3,4-thiadiazole based potent new nano-fungicides

  2020cited by this paper
• Thiadiazole derivatives as anticancer agents

  2020cited by this paper
• Correlations between molecular structure and biological activity in "logical series" of dietary chromone derivatives

  2020cited by this paper
• Structural Features of 1,3,4-Thiadiazole-Derived Ligands and Their Zn(II) and Cu(II) Complexes Which Demonstrate Synergistic Antibacterial Effects with Kanamycin

  2020cited by this paper
• Toxicity of the herbicides diuron, propazine, tebuthiuron, and haloxyfop to the diatom Chaetoceros muelleri

  2020cited by this paper
• Non-food bioactive natural forest products as insecticide candidates: Preparation, biological evaluation and molecular docking studies of novel N-(1,3-thiazol-2- yl)carboxamides fused (+)-nootkatone from Chamaecyparis nootkatensis [D. Don] Spach

  2020cited by this paper
• 5-Membered Mesoionic Insecticides: Synthesis and Evaluation of 1,3,4-Thiadiazol-4-ium-2-olates with High Affinity for the Insect Nicotinic Acetylcholine Receptor

  2019cited by this paper
• Non-food bioactive products: Design and semisynthesis of novel (+)-nootkatone derivatives containing isoxazoline moiety as insecticide candidates

  2019cited by this paper
• Synthesis of matrinic amide derivatives containing 1,3,4-thiadiazole scaffold as insecticidal/acaricidal agents.

  2018cited by this paper
• 2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

  2018cited by this paper
• Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

  2018cited by this paper
• Synthesis, Structure and Biological Activities of Novel 2-(Trifluoromethyl)- 6-arylimidazo[2,1-b][1,3,4]-thiadiazole (bis-)Mannich Base Derivatives Containing Substitutedpiperazine Moiety: Synthesis, Structure and Biological Activities of Novel 2-(Trifluoromethyl)- 6-arylimidazo[2,1-b][1,3,4]-thiadi

  2018cited by this paper
• The evolutionary origins of pesticide resistance

  2018cited by this paper
• Determination of malation, methidathion, and chlorpyrifos ethyl pesticides using acetylcholinesterase biosensor based on Nafion/Ag@rGO-NH2 nanocomposites

  2017cited by this paper
• Synthesis of 1,2,3-Thiadiazole and Thiazole-Based Strobilurins as Potent Fungicide Candidates.

  2017cited by this paper
• Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

  2017cited by this paper
• Anti-inflammatory, analgesic and COX-2 inhibitory activity of novel thiadiazoles in irradiated rats.

  2017cited by this paper
• Synthesis and biological activity of a new class of insecticides: the N-(5-aryl-1,3,4-thiadiazol-2-yl)amides.

  2017cited by this paper
• Synthesis and biological activities of (E)-β-farnesene analogues containing 1,2,3-thiadiazole

  2017cited by this paper
• Synthesis and antiviral evaluation of novel 1,3,4-oxadiazole/thiadiazole-chalcone conjugates.

  2017cited by this paper
• Various Bioactivity and Relationship of Structure-Activity of Matrine Analogues.

  2017cited by this paper
• 含亚胺基( E )- β -Farnesene类似物的设计、合成及生物活性研究

  2017cited by this paper
• Design, synthesis and antifungal activity of novel thioureas containing 1,3,4-thiadiazole and thioether skeleton

  2016cited by this paper
• Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan

  2016cited by this paper
• Synthesis and antifungal activity of dehydroabietic acid-based 1,3,4-thiadiazole-thiazolidinone compounds

  2016cited by this paper
• Synthesis and bioactivities of novel pyrazole oxime derivatives containing a 1,2,3-thiadiazole moiety.

  2016cited by this paper
• Synthesis and biological activities of novel 1,3,4-thiadiazole-containing pyrazole oxime derivatives.

  2016cited by this paper
• 1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.

  2015cited by this paper
• Design, Synthesis, and Herbicidal Evaluation of Novel Uracil Derivatives Containing 1,3,4-Thiadiazolyl Moiety: Novel Uracil Derivatives Containing 1,3,4-Thiadiazolyl Moiety

  2015cited by this paper
• Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety

  2015cited by this paper
• Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate

  2015cited by this paper
• Synthesis and fungicidal activity of novel 2-aryl-3-(1,3,4-thiadiazolyl)-6(8)-methyl-1,3-benzoxazines.

  2015cited by this paper
• Turning renewable resources into value-added products: Development of rosin-based insecticide candidates

  2015cited by this paper
• Synthesis and bioactivities of novel 1,3,4-oxadiazole derivatives containing 1,2,3-thiadiazole moiety

  2014cited by this paper
• Synthesis and insecticidal activities of N-(5-dehydroabietyl-1,3,4-thiadiazol-2-yl)-benzenesulfonamides

  2014cited by this paper
• Synthesis and Biological Activities of 3-Substituted-6-pyrazole-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

  2014cited by this paper
• Synthesis and Herbicidal Activity of 2-Aroxy-propanamides Containing Pyrimidine and 1,3,4-Thiadiazole Rings

  2014cited by this paper
• Synthesis and biological activities of novel 1,2,4-triazole derivatives containing 1,2,3-thiadiazole ring

  2014cited by this paper
• Synthesis and insecticidal activities of novel pyrazole oxime ether derivatives with different substituted pyridyl rings.

  2014cited by this paper
• Synthesis and biological activities of α-pinene-based dithiadiazoles

  2013cited by this paper
• Large-scale SAR analysis.

  2013cited by this paper
• Thiadiazole—a Promising Structure in Medicinal Chemistry

  2013cited by this paper
• Antioxidative activity of azoles and their influence on barley (Hordeum vulgare L.) seedlings and flavonoid accumulation.

  2013cited by this paper
• Tiadinil, a plant activator of systemic acquired resistance, boosts the production of herbivore-induced plant volatiles that attract the predatory mite Neoseiulus womersleyi in the tea plant Camellia sinensis

  2012cited by this paper
• 3-(1,3,4-Thiadiazole-2-yl)quinoline derivatives: synthesis, characterization and anti-microbial activity.

  2011cited by this paper
• Natural products as insecticides: the biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids.

  2001cited by this paper
• A novel isourazole herbicide, fluthiacet-methyl, is a potent inhibitor of protoporphyrinogen oxidase after isomerization by glutathione S-transferase

  1995cited by this paper

• No citing papers are available for this paper.