Brain glycogen in health and disease.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular Aspects of Medicine

• Publication date

  2015-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mam.2015.08.007PMID 26344371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glycogen phosphorylation and Lafora disease.

  2015cited by this paper
• PTG protein depletion rescues malin‐deficient Lafora disease in mouse

  2014cited by this paper
• Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

  2014cited by this paper
• Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease.

  2014cited by this paper
• Neuronal glycogen synthesis contributes to physiological aging

  2014cited by this paper
• Impairment in Long-Term Memory Formation and Learning-Dependent Synaptic Plasticity in Mice Lacking Glycogen Synthase in the Brain

  2013cited by this paper
• Inhibiting glycogen synthesis prevents lafora disease in a mouse model

  2013cited by this paper
• Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease.

  2012cited by this paper
• Deleterious effects of neuronal accumulation of glycogen in flies and mice

  2012cited by this paper
• Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy.

  2012cited by this paper
• Brain glycogen supercompensation following exhaustive exercise

  2012cited by this paper
• Glycogen and its metabolism: some new developments and old themes.

  2012cited by this paper
• PTG Depletion Removes Lafora Bodies and Rescues the Fatal Epilepsy of Lafora Disease

  2011cited by this paper
• Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

  2011cited by this paper
• Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis.

  2011cited by this paper
• Phosphate incorporation during glycogen synthesis and Lafora disease.

  2011cited by this paper
• Astrocyte-neuron lactate transport is required for long-term memory formation.

  2011cited by this paper
• Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene?

  2011cited by this paper
• Malin and laforin are essential components of a protein complex that protects cells from thermal stress

  2011cited by this paper
• Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

  2011cited by this paper
• Impaired autophagy in Lafora disease

  2010cited by this paper
• Laforin, the most common protein mutated in Lafora disease, regulates autophagy

  2010cited by this paper
• Brain glycogen and neurotransmitter levels in fast and slow methionine sulfoximine-selected mice.

  2010cited by this paper
• Glycogen hyperphosphorylation underlies lafora body formation

  2010cited by this paper
• Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin.

  2010cited by this paper
• Increased Endoplasmic Reticulum Stress and Decreased Proteasomal Function in Lafora Disease Models Lacking the Phosphatase Laforin

  2009cited by this paper
• Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress.

  2009cited by this paper
• The malin-laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system.

  2009cited by this paper
• The energy hypothesis of sleep revisited.

  2008cited by this paper
• Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration.

  2008cited by this paper
• Malin Decreases Glycogen Accumulation by Promoting the Degradation of Protein Targeting to Glycogen (PTG)*

  2008cited by this paper
• A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.

  2007cited by this paper
• Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy

  2007cited by this paper
• Corpora amylacea in mesial temporal lobe epilepsy: clinico-pathological correlations.

  2007cited by this paper
• Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.

  2005cited by this paper
• Brain glycogen re‐awakened

  2004cited by this paper
• Pallido-nigro-luysial atrophy with massive appearance of corpora amylacea in the CNS

  2004cited by this paper
• Immunochemical identification of ubiquitin and heat-shock proteins in corpora amylacea from normal aged and Alzheimer's disease brains

  2004cited by this paper
• Changes in brain glycogen after sleep deprivation vary with genotype.

  2003cited by this paper
• Glycogen Regulation and Functional Role in Mouse White Matter

  2003cited by this paper
• Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme‐specific antibodies

  2003cited by this paper
• Utilization of lectin-histochemistry in forensic neuropathology: lectin staining provides useful information for postmortem diagnosis in forensic neuropathology.

  2003cited by this paper
• Mutations in NHLRC1 cause progressive myoclonus epilepsy

  2003cited by this paper
• High Glycogen Levels in Brains of Rats with Minimal Environmental Stimuli: Implications for Metabolic Contributions of Working Astrocytes

  2002cited by this paper
• Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism

  2002cited by this paper
• Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats.

  2002cited by this paper
• Brain Glycogen Decreases with Increased Periods of Wakefulness: Implications for Homeostatic Drive to Sleep

  2002cited by this paper
• Immunoreactivity for Bcl‐2 and C‐Jun/AP1 in hippocampal corpora amylacea after ischaemia in humans

  2001cited by this paper
• Corpora Amylacea and Heat Shock Protein 27 in Ammon's Horn Sclerosis

  2000cited by this paper
• The carbohydrate deposits detected by histochemical methods in the molecular layer of the dentate gyrus in the hippocampal formation of patients with schizophrenia, Down's syndrome and dementia, and aged person

  2000cited by this paper
• Astrocytic Glycogen Influences Axon Function and Survival during Glucose Deprivation in Central White Matter

  2000cited by this paper
• Correlation between brain glycogen and convulsive state in mice submitted to methionine sulfoximine.

  2000cited by this paper
• A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2).

  1999cited by this paper
• Corpora-amylacea and the family of polyglucosan diseases.

  1999cited by this paper
• Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy

  1998cited by this paper
• Cloning, localization and induction of mouse brain glycogen synthase.

  1996cited by this paper
• Massive appearance of corpora amylacea in postnatal anoxic encephalopathy.

  1995cited by this paper
• Chimeric Muscle and Brain Glycogen Phosphorylases Define Protein Domains Governing Isozyme-specific Responses to Allosteric Activation (*)

  1995cited by this paper
• [Polysaccharide bodies: an unusual finding in a case of temporal epilepsy. Review of the literature].

  1993cited by this paper
• Corpora amylacea could be an indicator of neurodegeneration

  1993cited by this paper
• Occurrence of polyglucosan bodies in temporal lobe epilepsy.

  1992cited by this paper
• Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography.

  1992cited by this paper
• Localization of Glycogen Synthase in Brain

  1988cited by this paper
• Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes

  1986cited by this paper
• Synthetic and hydrolytic enzymes of glycogen in the normal and the irradiated rat brain.

  1970cited by this paper
• CONTROL OF GLYCOGEN LEVELS IN BRAIN 1

  1968cited by this paper

• Mapping glycogen accumulation and treatment effect in Pompe disease with saturation transfer MRI.

  2026cites this paper
• The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus.

  2026cites this paper
• Joan J. Guinovart (1947-2025).

  2025cites this paper
• Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review

  2025cites this paper
• Dietary trehalose reduced liver glycogen accumulation and promoted protein deposition in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂) fed a high-carbohydrate diet

  2025cites this paper
• Neuroprotective and Gastroprotective Effects of Rutin and Fluoxetine Co-Supplementation: A Biochemical Analysis in Nauphoeta cinerea.

  2025cites this paper
• Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review

  2024cites this paper
• Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States

  2023cites this paper
• Glycogen—Endoplasmic Reticulum Connection in the Liver

  2023cites this paper
• Lafora Disease: A Case Report and Evolving Treatment Advancements

  2023cites this paper
• The Pgb1 locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function

  2023cites this paper
• Twelve protections evolved for the brain, and their roles in extending its functional life

  2023cites this paper
• Histopathological features of the brain extracellular matrix from dogs with canine distemper

  2023cites this paper
• Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model

  2023cites this paper
• Does the Environmental Air Impact the Condition of the Vomeronasal Organ? A Mouse Model for Intensive Farming

  2023cites this paper
• Cell Heterogeneity Uncovered by Single-Cell RNA Sequencing Offers Potential Therapeutic Targets for Ischemic Stroke

  2022cites this paper
• Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review

  2021cites this paper
• Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora

  2021cites this paper
• The first central precocious puberty proteomic profiles revealed multiple metabolic networks and novel key disease-associated proteins

  2021cites this paper
• Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease

  2021cites this paper
• Histological and Immunohistochemical Characterization of Vomeronasal Organ Aging in Mice

  2021cites this paper
• Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease.

  2021cites this paper
• Serum profiling of anorexia nervosa: A 1H NMR-based metabolomics study.

  2021cites this paper
• Astrocytes in rare neurological conditions: Morphological and functional considerations

  2021cites this paper
• Lack of Astrocytic Glycogen Alters Synaptic Plasticity but Not Seizure Susceptibility

  2020cites this paper
• Arousal-induced cortical activity triggers lactate release from astrocytes

  2020cites this paper
• Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice

  2020cites this paper
• Dual-Specificity Phosphatases in Mental and Neurological Disorders.

  2020cites this paper
• Sugars and Sweeteners: Structure, Properties and in silico Modeling.

  2020cites this paper
• Polyglucosan body structure in Lafora disease.

  2020cites this paper
• The Motor Neuron-Like Cell Line NSC-34 and Its Parent Cell Line N18TG2 Have Glycogen that is Degraded Under Cellular Stress

  2020cites this paper
• Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction

  2019cites this paper
• Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates.

  2019cites this paper
• Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice

  2019cites this paper
• Glycogen phosphorylase of shrimp (Litopenaeus vannamei): Structure, expression and anti-WSSV function.

  2019cites this paper
• How glycogen sustains brain function: A plausible allosteric signaling pathway mediated by glucose phosphates

  2019cites this paper
• State-Dependent Changes in Brain Glycogen Metabolism.

  2019cites this paper
• Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future.

  2019cites this paper
• Glycogenolysis in Cerebral Cortex During Sensory Stimulation, Acute Hypoglycemia, and Exercise: Impact on Astrocytic Energetics, Aerobic Glycolysis, and Astrocyte-Neuron Interactions.

  2019cites this paper
• The Structure and the Regulation of Glycogen Phosphorylases in Brain.

  2019cites this paper
• From the seminal discovery of proteoglycogen and glycogenin to emerging knowledge and research on glycogen biology.

  2019cites this paper
• Glucose as a Major Antioxidant: When, What for and Why It Fails?

  2019cites this paper
• Inborn Errors of Metabolism with Hypoglycemia: Glycogen Storage Diseases and Inherited Disorders of Gluconeogenesis.

  2018cites this paper
• Brain alpha‐amylase: a novel energy regulator important in Alzheimer disease?

  2018influential citation
• Identification of Therapeutic Targets in a Glycogen Storage Disease Type IV Mouse Model

  2018cites this paper
• Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate

  2018cites this paper
• Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease

  2018cites this paper
• Lafora disease — from pathogenesis to treatment strategies

  2018cites this paper
• The ER – Glycogen Particle – Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy?

  2018cites this paper
• The unique evolution of the carbohydrate‐binding module CBM20 in laforin

  2018cites this paper
• Inborn Errors of Metabolism with Hypoglycemia Glycogen Storage Diseases and Inherited Disorders of Gluconeogenesis

  2018cites this paper
• Hyperglycemia-induced intramitochondrial glycogen granules: A potential mechanism of glucose cytotoxicity in brain of mice

  2018cites this paper
• Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila

  2018cites this paper
• Fundamentals of glycogen metabolism for coaches and athletes

  2018cites this paper
• Brain bioenergetics in rats with acute hyperphenylalaninemia

  2018cites this paper
• Technical and experimental features of Magnetic Resonance Spectroscopy of brain glycogen metabolism.

  2017cites this paper
• Suppression of leptin signaling reduces polyglucosan inclusions and seizure susceptibility in a mouse model for Lafora disease

  2017cites this paper
• Lafora disease in miniature Wirehaired Dachshunds

  2017cites this paper
• Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment.

  2017cites this paper
• Polysaccharides in Human Health Care

  2017cites this paper
• Glycogen distribution in adult and geriatric mice brains

  2017cites this paper
• Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan

  2017cites this paper
• Next generation sequencing analysis of soy glyceollins and 17-β estradiol: Effects on transcript abundance in the female mouse brain.

  2017cites this paper
• Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes

  2017cites this paper
• A straightforward assay for measuring glycogen levels and RpoS.

  2017cites this paper
• The structure of brain glycogen phosphorylase—from allosteric regulation mechanisms to clinical perspectives

  2017cites this paper
• Insights into Brain Glycogen Metabolism

  2016cites this paper
• Early care of acute hyperglycemia benefits the outcome of traumatic brain injury in rats.

  2016cites this paper
• FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy.

  2016cites this paper
• Effects of glyceollin on mRNA expression in the female mouse brain.

  2016cites this paper
• Biophysical characterization of laforin-carbohydrate interaction.

  2016cites this paper
• Bioenergetics and redox adaptations of astrocytes to neuronal activity

  2016cites this paper
• Third harmonic generation imaging for fast, label-free pathology of human brain tumors

  2016cites this paper
• Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy

  2016cites this paper
• Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

  2016cites this paper