Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission

No abstract is available for this paper.

• Publication year

  2025

• Venue

  bioRxiv

• Publication date

  2025-10-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/2025.10.27.684817
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef

  2025cited by this paper
• AXIN1 boosts antiviral response through IRF3 stabilization and induced phase separation

  2024cited by this paper
• Replicative fitness and pathogenicity of primate lentiviruses in lymphoid tissue, primary human and chimpanzee cells: relation to possible jumps to humans

  2024cited by this paper
• Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

  2024influential reference
• A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency

  2024cited by this paper
• Recent Insights in Pyrin Inflammasome Activation: Identifying Potential Novel Therapeutic Approaches in Pyrin-Associated Autoinflammatory Syndromes

  2023cited by this paper
• IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion

  2023cited by this paper
• Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

  2022cited by this paper
• β-catenin regulates HIV latency and modulates HIV reactivation

  2022cited by this paper
• Innate immunity: the first line of defense against SARS-CoV-2

  2022cited by this paper
• AP‐1 and NF‐κB synergize to transcriptionally activate latent HIV upon T‐cell receptor activation

  2021cited by this paper
• SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy

  2021cited by this paper
• Discovering antiviral restriction factors and pathways using genetic screens

  2021cited by this paper
• Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems

  2021cited by this paper
• An improved method for high-throughput quantification of autophagy in mammalian cells

  2020cited by this paper
• Potential for Virus Endogenization in Humans through Testicular Germ Cell Infection: the Case of HIV

  2020cited by this paper
• Key Viral Adaptations Preceding the AIDS Pandemic.

  2019influential reference
• Interplay between Intrinsic and Innate Immunity during HIV Infection

  2019cited by this paper
• SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model

  2018cited by this paper
• Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing

  2018cited by this paper
• The Inhibition of HIV-1 Entry Imposed by Interferon Inducible Transmembrane Proteins Is Independent of Co-Receptor Usage

  2018cited by this paper
• Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1

  2018cited by this paper
• TRIM23 mediates virus-induced autophagy via activation of TBK1

  2017cited by this paper
• Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model

  2017cited by this paper
• TreeTime: Maximum-likelihood phylodynamic analysis

  2017cited by this paper
• Inflammasomes: mechanism of assembly, regulation and signalling

  2016cited by this paper
• Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

  2016cited by this paper
• HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expression

  2015cited by this paper
• Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

  2015cited by this paper
• MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

  2014cited by this paper
• IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread

  2014cited by this paper
• IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

  2014cited by this paper
• The immunological function of familial Mediterranean fever disease protein Pyrin

  2014cited by this paper
• Proximity to PML nuclear bodies regulates HIV-1 latency in CD4+ T cells.

  2013cited by this paper
• Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses.

  2013cited by this paper
• The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry

  2013cited by this paper
• Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes

  2013cited by this paper
• IFITM Proteins Restrict Viral Membrane Hemifusion

  2013cited by this paper
• Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation.

  2012cited by this paper
• Role of β-Catenin/TCF-4 Signaling in HIV Replication and Pathogenesis: Insights to Informing Novel Anti-HIV Molecular Therapeutics

  2011cited by this paper
• STING is a direct innate immune sensor of cyclic-di-GMP

  2011cited by this paper
• Origins of HIV and the AIDS pandemic.

  2011cited by this paper
• Heat Shock Protein 70 Inhibits HIV-1 Vif-mediated Ubiquitination and Degradation of APOBEC3G*

  2011cited by this paper
• Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.

  2010cited by this paper
• Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

  2009cited by this paper
• Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

  2009cited by this paper
• FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity.

  2008cited by this paper
• FoxP3 Enhances HIV-1 Gene Expression by Modulating NFκB Occupancy at the Long Terminal Repeat in Human T Cells*

  2007cited by this paper
• Effect of DNA Repair Protein Rad18 on Viral Infection

  2006cited by this paper
• The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo.

  2005cited by this paper
• Jurkat T cells and development of the T-cell receptor signalling paradigm

  2004cited by this paper
• Heat Shock Protein 70 Protects Cells from Cell Cycle Arrest and Apoptosis Induced by Human Immunodeficiency Virus Type 1 Viral Protein R

  2004cited by this paper
• Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120

  2003cited by this paper
• Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy

  2002cited by this paper
• Ability of the V3 Loop of Simian Immunodeficiency Virus To Serve as a Target for Antibody-Mediated Neutralization: Correlation of Neutralization Sensitivity, Growth in Macrophages, and Decreased Dependence on CD4

  2001cited by this paper
• Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes

  1999cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

  1998influential reference
• Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

  1995cited by this paper
• Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1

  1995cited by this paper
• Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene

  1994cited by this paper

• No citing papers are available for this paper.