Hypothesis: A biological role for germline transcription in the mechanism of V(D)J recombination – implications for initiation of allelic exclusion

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Immunology and Cell Biology

• Publication date

  2006-04-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1440-1711.2006.01437.xPMID 16594898
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elucidation of IgH intronic enhancer functions via germ-line deletion.

  2005cited by this paper
• Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene

  2005cited by this paper
• Epigenetic ontogeny of the Igk locus during B cell development

  2005cited by this paper
• Antisense intergenic transcription in V(D)J recombination

  2004cited by this paper
• Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.

  2004cited by this paper
• An lmmunoglobulin Heavy Chain Variable Region Gene Is Generated from Three Segments of DNA : VH

  2004cited by this paper
• Biallelic Germline Transcription at the κ Immunoglobulin Locus

  2003cited by this paper
• The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation.

  2003cited by this paper
• Faculty Opinions recommendation of Biallelic germline transcription at the kappa immunoglobulin locus.

  2003cited by this paper
• Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.

  2002cited by this paper
• Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation

  2002cited by this paper
• Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

  2002cited by this paper
• Differential accessibility at the κ chain locus plays a role in allelic exclusion

  2002cited by this paper
• B Cell Development Arrest Upon Insertion of a neo Gene Between JH and Eμ: Promoter Competition Results in Transcriptional Silencing of Germline JH and Complete V(D)J Rearrangements1

  2002cited by this paper
• V(D)J recombination: RAG proteins, repair factors, and regulation.

  2002cited by this paper
• Differential accessibility at the kappa chain locus plays a role in allelic exclusion.

  2002cited by this paper
• Stepwise activation of the immunoglobulin μ heavy chain gene locus

  2001cited by this paper
• Chromatin Remodeling at the Ig Loci Prior to V(D)J Recombination1

  2001cited by this paper
• V(D)J recombination is not activated by demethylation of the kappa locus.

  2000cited by this paper
• Stimulation of V(D)J recombination by histone acetylation.

  2000cited by this paper
• Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

  1999cited by this paper
• Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

  1999cited by this paper
• Chromatin remodeling directly activates V(D)J recombination.

  1999cited by this paper
• Evidence that the Igkappa gene MAR regulates the probability of premature V-J joining and somatic hypermutation.

  1999cited by this paper
• Evidence that Immunoglobulin VH-DJ Recombination Does Not Require Germ Line Transcription of the Recombining Variable Gene Segment

  1998cited by this paper
• Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers

  1998cited by this paper
• V(D)J Recombination: Modulation of RAG1 and RAG2 Cleavage Activity on 12/23 Substrates by Whole Cell Extract and DNA-bending Proteins

  1997cited by this paper
• Stimulation of V(D)J cleavage by high mobility group proteins

  1997cited by this paper
• Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement.

  1996cited by this paper
• Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

  1996cited by this paper
• The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

  1996cited by this paper
• Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.

  1996cited by this paper
• The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.

  1996cited by this paper
• DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

  1996cited by this paper
• The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate

  1995cited by this paper
• Conservation of sequence in recombination signal sequence spacers.

  1994cited by this paper
• Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells

  1994cited by this paper
• A second promoter and enhancer element within the immunoglobulin heavy chain locus

  1994cited by this paper
• The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region

  1993cited by this paper
• Molecular structure of nucleic acids : a structure for deoxyribose nucleic acid

  1993cited by this paper
• Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

  1993cited by this paper
• Methylation status of immunoglobulin kappa gene segments correlates with their recombination potential.

  1993cited by this paper
• V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

  1993cited by this paper
• Rag-1: a topoisomerase?

  1993cited by this paper
• Methylation status of immunoglobulin x e segments correlates with their recombination potential

  1993cited by this paper
• The nobel lectures in immunology the nobel prize for physiology or medicine, 1972 : antibody structure and molecular immunology

  1991cited by this paper
• Antibody Structure and Molecular Immunology

  1991cited by this paper
• Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation

  1991cited by this paper
• The mouse IgH 3′‐enhancer

  1991cited by this paper
• An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus.

  1991cited by this paper
• Base-pairing shift in the major groove of (CA)n tracts by B-DNA crystal structures

  1991cited by this paper
• Lecture for the Nobel Prize for physiology or medicine 1972: Structural studies of immunoglobulins. 1972.

  1991cited by this paper
• RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.

  1990cited by this paper
• Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells

  1990cited by this paper
• The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?

  1990cited by this paper
• HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene

  1990cited by this paper
• A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

  1990cited by this paper
• V(D)J recombination: a functional definition of the joining signals.

  1989cited by this paper
• The immunoglobulin kappa locus contains a second, stronger B‐cell‐specific enhancer which is located downstream of the constant region.

  1989cited by this paper
• The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated

  1988cited by this paper
• Supercoiling of the DNA template during transcription.

  1987cited by this paper
• The clonal-selection theory.

  1987cited by this paper
• The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

  1987cited by this paper
• Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites.

  1986cited by this paper
• Regulation of the assembly and expression of variable-region genes.

  1986cited by this paper
• Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon

  1985cited by this paper
• Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.

  1985cited by this paper
• A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene.

  1984cited by this paper
• Correlation of lac operator DNA imino proton exchange kinetics with its function.

  1984cited by this paper
• Fine mapping of an immunoglobulin gene activator

  1984cited by this paper
• Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

  1984cited by this paper
• A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

  1984cited by this paper
• Immunoglobulin gene transcription is activated by downstream sequence elements.

  1983cited by this paper
• A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

  1983cited by this paper
• A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

  1983cited by this paper
• Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines

  1982cited by this paper
• Transcription of the unrearranged mouse C kappa locus: sequence of the initiation region and comparison of activity with a rearranged V kappa-C kappa gene.

  1981cited by this paper
• Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

  1981cited by this paper
• An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.

  1980cited by this paper
• Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain.

  1980cited by this paper
• A modification of jerne's theory of antibody production using the concept of clonal selection

  1976cited by this paper
• Somatic generation of antibody diversity.

  1976cited by this paper
• Structural Studies of Immunoglobulins

  1973cited by this paper
• RABBIT LYMPHOID CELLS DIFFERENTIATED WITH RESPECT TO α-, γ-, AND µ- HEAVY POLYPEPTIDE CHAINS AND TO ALLOTYPIC MARKERS AA1 AND AA2

  1966cited by this paper
• CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUES

  1965cited by this paper
• Preventive Medicine: Principles of Prevention in Occurrence and Progression of Disease

  1960cited by this paper
• Molecular structure of deoxypentose nucleic acids.

  1953cited by this paper
• role in

  year unknowncited by this paper

• Mechanistic insights from molecular microbiology into the production of immunological and neuronal diversity

  2022cites this paper
• Roles of Igh Intronic Enhancer Eμ in Clonal Selection at the Pre-B to Immature B Cell Transition and in the Elimination of Autoreactive B Cells

  2014influential citation