Association between serum omentin-1 concentrations and body composition measured by dual-energy X-ray absorptiometry in Japanese elementary school-aged children

Omentin-1 (also known as intelectin-1) is a novel adipokine associated with metabolic diseases. However, its physiological role in body composition remains incompletely understood. Therefore, this study aimed to investigate the association between the circulating omentin-1 levels and whole-body and regional body composition parameters measured using dual-energy X-ray absorptiometry (DXA). A population-based cross-sectional survey was conducted among school-aged children in Hamamatsu, Japan. Serum adipokine levels were measured using enzyme-linked immunosorbent assay, and associations between omentin-1 levels and DXA-based parameters were evaluated by multiple regression analysis after adjusting for potential confounding factors. The final study included 392 participants (192 boys, 200 girls, 75.2% of the source population; mean age 11.2 ± 0.3 years). Serum omentin-1 levels showed a significantly inverse association with nearly all DXA-based fat mass parameters. Inverse correlations were observed with fat-free soft tissue mass and serum leptin levels, whereas positive correlations were noted with adiponectin levels. The mean values for various body fat parameters, fat-free soft tissue mass, body mass index, and waist circumference were significantly decreased across tertiles of serum omentin-1 levels from lowest to the highest after adjusting for potential confounders. Our results demonstrate that Japanese school-aged children with higher fat mass tended to have lower serum omentin-1 levels. These findings provide crucial insights into the link between omentin-1 levels and body composition, which may contribute to early health interventions for metabolic improvement.

• Publication year

  2025

• Venue

  Journal of Physiological Anthropology

• Publication date

  2025-11-07

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/s40101-025-00406-6PMID 41204367PMCID 12595685
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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