Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Molecular Endocrinology

• Publication date

  1992-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/MEND.6.11.1480174PMID 1480174
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.

  1992cited by this paper
• A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C

  1992cited by this paper
• Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

  1991cited by this paper
• The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor.

  1991cited by this paper
• Raf-1: a kinase currently without a cause but not lacking in effects.

  1991cited by this paper
• Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.

  1991cited by this paper
• Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.

  1991cited by this paper
• Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

  1991cited by this paper
• Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines.

  1991cited by this paper
• SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.

  1991cited by this paper
• Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.

  1990cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper
• Ligand-induced transformation by a noninternalizing epidermal growth factor receptor.

  1990cited by this paper
• The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC‐gamma.

  1990cited by this paper
• Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.

  1990cited by this paper
• Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization

  1989cited by this paper
• Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.

  1989cited by this paper
• Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover.

  1989cited by this paper
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  1989cited by this paper
• Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.

  1989cited by this paper
• Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.

  1989cited by this paper
• Altered sensitivity of system A amino acid transport to ouabain in normal and transformed C3H-10T1/2 cells during the cell cycle.

  1989cited by this paper
• Global modulation of the epidermal growth factor receptor is triggered by occupancy of only a few receptors. Evidence for a binary regulatory system in normal human fibroblasts.

  1989cited by this paper
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  1988cited by this paper
• Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo.

  1988cited by this paper
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  1988cited by this paper
• Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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  1985cited by this paper
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  1984cited by this paper
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  1984cited by this paper
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  1984cited by this paper
• Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

  1984cited by this paper
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  1984cited by this paper
• C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

  1984cited by this paper
• beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

  1983cited by this paper
• Epidermal growth factor (EGF) is required only during the traverse of early G1 in PDGF stimulated density-arrested BALB/c-3T3 cells.

  1983cited by this paper
• Further purification of epidermal growth factor by high-performance liquid chromatography.

  1982cited by this paper
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  1981cited by this paper
• Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

  1980cited by this paper
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  1972cited by this paper

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