Utility of Muropeptide Ligase for Identification of Inhibitors of the Cell Wall Biosynthesis Enzyme MurF

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2006-01-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/AAC.50.1.230-236.2006PMID 16377691PMCID PMC1346814
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of a Dithiazoline Inhibitor of Escherichia colil,d-Carboxypeptidase A

  2005cited by this paper
• UDP-N-acetylmuramic acid (UDP-MurNAc) is a potent inhibitor of MurA (enolpyruvyl-UDP-GlcNAc synthase).

  2005cited by this paper
• Structure-activity relationships of novel potent MurF inhibitors.

  2004cited by this paper
• Structure—Activity Relationships of Novel Potent MurF Inhibitors.

  2004influential reference
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  2003cited by this paper
• Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors

  2002cited by this paper
• Structure and function of the Mur enzymes: development of novel inhibitors

  2002cited by this paper
• New (and not so new) antibacterial targets - from where and when will the novel drugs come?

  2002cited by this paper
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  2000cited by this paper
• Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.

  2000cited by this paper
• Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis

  1999cited by this paper
• A defect in cell wall recycling triggers autolysis during the stationary growth phase of Escherichia coli

  1999cited by this paper
• Aminoalkylphosphinate inhibitors of D-Ala-D-Ala adding enzyme

  1998cited by this paper
• ENGINEERING A CELL-FREE MUREIN BIOSYNTHETIC PATHWAY : COMBINATORIAL ENZYMOLOGY IN DRUG DISCOVERY

  1998cited by this paper
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  1997cited by this paper
• Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan

  1996cited by this paper
• Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: use of a glutathione S-transferase fusion.

  1996cited by this paper
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• Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase.

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• Components of Bacterial Cell Walls as Targets for Searching for New Antibacterial Compounds: Methods of Study

  2025cites this paper
• Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target

  2023cites this paper
• Identification of fungus-growing termite-associated halogenated-PKS maduralactomycin a as a potential inhibitor of MurF protein of multidrug-resistant Acinetobacter baumannii

  2023cites this paper
• Breaking down the cell wall: Still an attractive antibacterial strategy

  2022cites this paper
• Molecular insight into the binding mode of thieno[3,2-c]pyrazol-3-ols with Streptococcus pneumoniae MurF enzyme by combined molecular modeling approach

  2022cites this paper
• Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics.

  2020cites this paper
• An explorative study on diarylquinoline-based inhibitor targeting Enterococcus faecium MurF

  2020cites this paper
• Peptidoglycan pathways: there are still more!

  2019cites this paper
• Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen

  2019cites this paper
• Binding mode analysis, dynamic simulation and binding free energy calculations of the MurF ligase from Acinetobacter baumannii.

  2017cites this paper
• Strand-specific transcriptomes of Enterohemorrhagic Escherichia coli in response to interactions with ground beef microbiota: interactions between microorganisms in raw meat

  2017cites this paper
• Insight into the structural requirements of thiophene-3-carbonitriles-based MurF inhibitors by 3D-QSAR, molecular docking and molecular dynamics study

  2017cites this paper
• Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

  2014cites this paper
• Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.

  2014cites this paper
• Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

  2013cites this paper
• Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa.

  2013cites this paper
• A Novel in vivo Cell‐Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli

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• Challenges of Antibacterial Discovery

  2011cites this paper
• Peptidoglycan biosynthesis machinery: A rich source of drug targets

  2011cites this paper
• The Synthesis of Novel 2,4,6-Trisubstituted 1,3,5-Triazines: A Search for Potential MurF Enzyme Inhibitors.

  2010cites this paper
• A novel assay of bacterial peptidoglycan synthesis for natural product screening

  2009cites this paper
• MurF Inhibitors with Antibacterial Activity: Effect on Muropeptide Levels

  2009cites this paper
• Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF

  2008cites this paper
• How Bacteria Consume Their Own Exoskeletons (Turnover and Recycling of Cell Wall Peptidoglycan)

  2008cites this paper
• Cytoplasmic steps of peptidoglycan biosynthesis.

  2008cites this paper
• Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening.

  2008cites this paper
• Emerging bacterial enzyme targets.

  2007cites this paper
• Naphthyl Tetronic Acids as Multi‐Target Inhibitors of Bacterial Peptidoglycan Biosynthesis

  2007cites this paper
• Biochemical Characterization and Physiological Properties of Escherichia coli UDP- N -Acetylmuramate: L -Alanyl- (cid:2) - D -Glutamyl- meso Diaminopimelate Ligase (cid:1)

  2007cites this paper
• Development of novel inhibitors targeting intracellular steps of peptidoglycan biosynthesis.

  2007cites this paper
• Biochemical Characterization and Physiological Properties of Escherichia coli UDP-N-Acetylmuramate:l-Alanyl-γ-d-Glutamyl-meso- Diaminopimelate Ligase

  2007cites this paper
• Génomique fonctionnelle des protéines de division cellulaire et du peptidoglycane : développement de nouveaux agents antibactériens

  2007cites this paper
• A MurF Inhibitor That Disrupts Cell Wall Biosynthesis in Escherichia coli

  2007cites this paper