Laser Photobiomodulation of Human Dermal Fibroblasts Combined With Plasma Rich in Growth Factors and Platelet‐Rich Plasma: A Comparative In Vitro Analysis

Sameerah Hasan Abdullah,M. Mokhtari-Dizaji,Zeinab Hormozi-Moghaddam,Mohsen Bakhshandeh,M. Nilforoshzadeh

Published 2025 in Photodermatology, Photoimmunology & Photomedicine

ABSTRACT

Platelet‐rich plasma (PRP) and plasma rich in growth factors (PRGF) are autologous preparations widely applied in regenerative medicine because of their potential to enhance tissue repair and cellular activity. Low‐level laser therapy (LLLT) has also been reported to promote fibroblast proliferation and mitochondrial activity. This study aimed to investigate the combined effects of PRP, PRGF, and LLLT on human dermal fibroblasts (HDFCs).

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