Cognitive reserve predicts baseline tau burden in the U.S. POINTER trial imaging cohort

Valory N. Pavlik,Christopher J. Weber,J. Masdeu,Laura D. Baker,Melissa M. Yu,Michele York,R. Whitmer,Susan M. Landau,Theresa M. Harrison,Tomas M Holland,Laura Lovato

Published 2025 in Alzheimer's & Dementia

ABSTRACT

Higher cognitive reserve (CR) is associated with reduced dementia risk. We hypothesized that higher CR is associated with less baseline Alzheimer's disease (AD) pathology in the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) cohort.

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