Structure of the bacteriophage PhiKZ non-virion RNA polymerase bound to a p119L open promoter analogue

Bacteriophage ΦKZ is a massive bacterial virus with potential as a therapy for Pseudomonas aeruginosa, which forms a bacteriophage nucleus in infected cells to exclude the host immune system, and transcribes its genes with its own, non-canonical multi-subunit RNA polymerase. The structure of this polymerase in the process of binding an analogue of its cognate promoter is resolved, revealing an unanticipated method of promoter consensus recognition involving the β-like, rather than the σ-factor-like subunit.

• Publication year

  2026

• Venue

  IUCrJ

• Publication date

  2026-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1107/S2052252525009273PMID 41212033PMCID 12809450
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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