Cluster Analysis to Identify Distinct Asthma Phenotypes in the ATLANTIS Cohort

P. Kuks,Tatiana Karp,J. Hartman,Monica Kraft,S. Siddiqui,Leonardo Fabbri,B. Beghé,Klaus F. Rabe,A. Papi,Christopher E Brightling,Dave Singh,Xingnan Li,J. Kocks,Ulrica Scaffidi-Argentina,H. Kerstjens,I. Heijink,S. Pouwels,D.-J. Slebos,Maarten van den Berge

Published 2025 in Allergy. European Journal of Allergy and Clinical Immunology

ABSTRACT

Previous cluster analyses have identified subgroups of asthma. However, only a few studies included parameters of small airways dysfunction (SAD), or gene expression profiles reflecting underlying disease mechanisms. We aimed to identify clinically distinct asthma phenotypes, beyond GINA asthma severity, using available data from the ATLANTIS study which focused on identifying the prevalence of SAD in asthma and its role in asthma control, exacerbations and quality of life.

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