SCIENCE@home

Toward a treat-to-target strategy in juvenile dermatomyositis: what are the suitable targets and optimal timing of their achievement?

Jayne M. MacMahon,Angelo Ravelli,A. Rebollo-Giménez,V. Natoli,Chiara Campone,F. Bovis,Tomo Nozawa,Y. I. Goh,A. Consolaro,Brian M. Feldman,S. Rosina

Published 2025 in Arthritis & Rheumatology

ABSTRACT

INTRODUCTION Juvenile dermatomyositis (JDM) is a rare autoimmune condition. The treat-to-target (T2T) strategy has garnered interest in paediatric rheumatology. It is based on defining clear therapeutic targets, with frequent disease activity monitoring, and adjustment of the treatments if targets are not met within a defined time frame. Recently, an international Task Force of experts launched an initiative aimed at the development of recommendations for the adoption of T2T strategy in JDM. This study was done to support those recommendations. OBJECTIVES We aimed to determine the time to treatment response in patients with JDM, to better inform the development of a T2T strategy in JDM. METHODS This is a retrospective review of patients with a physician-confirmed diagnosis of JDM, followed at two tertiary care centres-the IRCCS Istituto Giannina Gaslini (Gaslini), and The Hospital for Sick Children (SickKids). Demographic and clinical data were obtained on all patients with JDM during the first two years following diagnosis. Kaplan-Meier survival curves were used to determine time to outcome definitions. RESULTS 187 patients were identified across two sites; the mean age of diagnosis was 8 years. On average, patients with JDM achieved normalization of muscle enzymes and muscle remission 3 and 6 months after treatment initiation, respectively. Skin remission occurred within 12 months after starting treatment. Time to reach inactive disease varied between the sites, with median time 10.3 months (Gaslini) and 8.8 months (SickKids). CONCLUSIONS This study provides real-world data for potential timelines to target with a T2T strategy for JDM.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-37 of 37 references · Page 1 of 1

CITED BY

  • No citing papers are available for this paper.

Showing 0-0 of 0 citing papers · Page 1 of 1