Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells

Recent studies add to our understanding of T cell residency in the human bone marrow (BM). In the May 2025 issue of EJI, Schneider Revueltas et al. demonstrate that CD69− CD4+ and CD8+ memory T cells, presumed to be recirculating, have a distinct transcriptional cluster profile and a distinct TCR repertoire from their blood counterparts. These findings are in line with CD69− memory T cells taking up residence in the BM, similar to their CD69+ counterparts. In parallel, Pulvirenti et al. identify a subset of CD69+EOMES+GzmK+ Tr1‐like cells in the BM maintained by IL‐15. Together, these studies refine our understanding of the BM as a heterogeneous immune niche and suggest a broader definition of resident cells within this tissue.

• Publication year

  2025

• Venue

  European Journal of Immunology

• Publication date

  2025-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/eji.70083PMID 41211791PMCID 12599270
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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