NK and T cell evasion mechanism of human cytomegalovirus

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Archives of Virology

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00705-025-06457-5PMID 41214228
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Natural killer cells in antiviral immunity

  2021cited by this paper
• Functional Profile of Human Cytomegalovirus Genes and Their Associated Diseases: A Review

  2020cited by this paper
• Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

  2019cited by this paper
• Subversion of Immune Response by Human Cytomegalovirus

  2019cited by this paper
• Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

  2019cited by this paper
• Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses

  2018cited by this paper
• HCMV-Encoded NK Modulators: Lessons From in vitro and in vivo Genetic Variation

  2018cited by this paper
• Functional annotation of human cytomegalovirus gene products: an update

  2014cited by this paper
• NK cells and their ability to modulate T cells during virus infections.

  2014cited by this paper
• Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation

  2014cited by this paper
• Classical and non-classical MHC I molecule manipulation by human cytomegalovirus: so many targets—but how many arrows in the quiver?

  2014influential reference
• Modulation of NK Cell Function by Genetically Coupled C-Type Lectin-Like Receptor/Ligand Pairs Encoded in the Human Natural Killer Gene Complex

  2013cited by this paper
• The C-Terminal Amino Acid of the MHC-I Heavy Chain Is Critical for Binding to Derlin-1 in Human Cytomegalovirus US11-Induced MHC-I Degradation

  2013cited by this paper
• Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral Defenses

  2013cited by this paper
• Co‐expression of HLA‐B7 and HLA‐B27 alleles is associated with B7‐restricted immunodominant responses following influenza infection

  2013cited by this paper
• Decoding Human Cytomegalovirus

  2012cited by this paper
• Human Cytomegalovirus UL40 Signal Peptide Regulates Cell Surface Expression of the NK Cell Ligands HLA-E and gpUL18

  2012cited by this paper
• Human cytomegalovirus transcriptome activity differs during replication in human fibroblast, epithelial and astrocyte cell lines

  2012cited by this paper
• Human cytomegalovirus UL7, a homologue of the SLAM‐family receptor CD229, impairs cytokine production

  2011cited by this paper
• Cytomegalovirus and Tumors: Two Players for One Goal-Immune Escape

  2011cited by this paper
• Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

  2011cited by this paper
• The ancient cell death suppressor BAX inhibitor-1.

  2011cited by this paper
• The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells

  2011cited by this paper
• Effect of NKG2D ligand expression on host immune responses

  2010cited by this paper
• Protein disulphide isomerase is required for signal peptide peptidase‐mediated protein degradation

  2010cited by this paper
• Transmembrane BAX Inhibitor Motif Containing (TMBIM) Family Proteins Perturbs a trans-Golgi Network Enzyme, Gb3 Synthase, and Reduces Gb3 Biosynthesis*

  2010cited by this paper
• The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation

  2010cited by this paper
• Structure of the HCMV UL16-MICB Complex Elucidates Select Binding of a Viral Immunoevasin to Diverse NKG2D Ligands

  2010cited by this paper
• Intracellular Sequestration of the NKG2D Ligand ULBP3 by Human Cytomegalovirus

  2010influential reference
• The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

  2009cited by this paper
• NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142

  2009cited by this paper
• Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells.

  2009cited by this paper
• Immunobiology of Human Cytomegalovirus: from Bench to Bedside

  2009cited by this paper
• ULBP6/RAET1L is an additional human NKG2D ligand

  2009cited by this paper
• Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor

  2008cited by this paper
• Immune Modulation by the Human Cytomegalovirus-Encoded Molecule UL18, a Mystery Yet to Be Solved

  2008cited by this paper
• Human NK cells can control CMV infection in the absence of T cells.

  2008cited by this paper
• Cytomegalovirus immune evasion.

  2008cited by this paper
• Human Cytomegalovirus UL18 Utilizes US6 for Evading the NK and T-Cell Responses

  2008cited by this paper
• Modulation of natural killer cells by human cytomegalovirus.

  2008cited by this paper
• Evolutionary struggles between NK cells and viruses

  2008cited by this paper
• Host Immune System Gene Targeting by a Viral miRNA

  2007cited by this paper
• Purification and HPLC-MS analysis of a naturally processed HCMV-derived peptide isolated from the HEK-293T/HLA-E+/Ul40+ cell transfectants and presented at the cell surface in the context of HLA-E.

  2007cited by this paper
• The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1− NK Cells1

  2007cited by this paper
• Activation, coactivation, and costimulation of resting human natural killer cells

  2006cited by this paper
• Ubiquitination of MHC Class I Heavy Chains Is Essential for Dislocation by Human Cytomegalovirus-encoded US2 but Not US11*

  2006cited by this paper
• Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

  2006cited by this paper
• Human Cytomegalovirus-Encoded UL16 Discriminates MIC Molecules by Their α2 Domains1

  2006cited by this paper
• Natural killer cells as an initial defense against pathogens

  2006cited by this paper
• Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142.

  2006cited by this paper
• CHAPTER 7 HUMAN CYTOMEGALOVIRUS-ENCODED US 2 AND US 11 TARGET UNASSEMBLED MHC CLASS I HEAVY CHAINS FOR DEGRADATION

  2006cited by this paper
• Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.

  2006cited by this paper
• The Immediate Early 2 Protein of Human Cytomegalovirus (HCMV) Mediates the Apoptotic Control in HCMV Retinitis through Up-Regulation of the Cellular FLICE-Inhibitory Protein Expression1

  2006influential reference
• Regulation of NKG2D ligand gene expression.

  2006cited by this paper
• Human Cytomegalovirus Encodes an MHC Class I-Like Molecule (UL142) That Functions to Inhibit NK Cell Lysis1

  2005cited by this paper
• Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18.

  2005cited by this paper
• Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.

  2005cited by this paper
• Human Cytomegalovirus-Encoded Interleukin-10 Homolog Inhibits Maturation of Dendritic Cells and Alters Their Functionality

  2004cited by this paper
• Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D1

  2004cited by this paper
• A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

  2004cited by this paper
• Major Human Cytomegalovirus Structural Protein pp65 (ppUL83) Prevents Interferon Response Factor 3 Activation in the Interferon Response

  2004cited by this paper
• Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol

  2003cited by this paper
• Human Cytomegalovirus-Encoded US2 Differentially Affects Surface Expression of MHC Class I Locus Products and Targets Membrane-Bound, but Not Soluble HLA-G1 for Degradation 1

  2003cited by this paper
• Faculty Opinions recommendation of Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.

  2003cited by this paper
• Intracellular Retention of the MHC Class I-Related Chain B Ligand of NKG2D by the Human Cytomegalovirus UL16 Glycoprotein1

  2003cited by this paper
• Human Cytomegalovirus Glycoprotein UL16 Causes Intracellular Sequestration of NKG2D Ligands, Protecting Against Natural Killer Cell Cytotoxicity

  2003cited by this paper
• Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells

  2003cited by this paper
• Publisher's Note

  2003cited by this paper
• The MHC Class I Homolog of Human Cytomegalovirus Is Resistant to Down-Regulation Mediated by the Unique Short Region Protein (US)2, US3, US6, and US11 Gene Products1

  2002cited by this paper
• Human cytomegalovirus and immunopathology

  2002cited by this paper
• Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48

  2002cited by this paper
• Viral immune evasion: a masterpiece of evolution

  2002cited by this paper
• Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18

  2002cited by this paper
• UL40-mediated NK evasion during productive infection with human cytomegalovirus

  2002cited by this paper
• ULBP1, 2, 3: novel MHC class I‐related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells

  2001cited by this paper
• Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes1

  2001cited by this paper
• Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific Manner

  2001cited by this paper
• ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.

  2001cited by this paper
• Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

  2001cited by this paper
• The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

  2001cited by this paper
• Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2).

  2000cited by this paper
• The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18.

  1999cited by this paper
• Cytomegalovirus encodes a potent alpha chemokine.

  1999cited by this paper
• Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells

  1999cited by this paper
• HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

  1998cited by this paper
• Viral strategies of immune evasion.

  1998cited by this paper
• The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

  1997cited by this paper
• The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

  1997cited by this paper
• Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains

  1997cited by this paper
• Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.

  1996cited by this paper
• Identification of the human cytomegalovirus G protein-coupled receptor homologue encoded by UL33 in infected cells and enveloped virus particles.

  1996cited by this paper
• Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

  1995cited by this paper
• Characterization of a structurally tricistronic gene of human cytomegalovirus composed of U(s)18, U(s)19, and U(s)20

  1993cited by this paper

• No citing papers are available for this paper.