Validation of a Clinical and Polygenic Risk Prediction Model for Ovarian Cancer in the Nurses’ Health Study

In this study, we have validated the predictive performance of a combined clinical and polygenic model for ovarian cancer. Accurate risk assessment enables more efficient allocation of preventive interventions, including intensified surveillance and consideration of risk-reducing salpingo-oophorectomy among women at elevated risk.

• Publication year

  2025

• Venue

  Cancer Prevention Research

• Publication date

  2025-11-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1158/1940-6207.CAPR-24-0528PMID 41215703PMCID 12877746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Normal Risk Ovarian Screening Study: 21-Year Update

  2024cited by this paper
• Tumour stage, treatment, and survival of women with high-grade serous tubo-ovarian cancer in UKCTOCS: an exploratory analysis of a randomised controlled trial

  2023cited by this paper
• NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024.

  2023cited by this paper
• A combined clinical and genetic model for predicting risk of ovarian cancer

  2022influential reference
• UK Biobank: a globally important resource for cancer research

  2022influential reference
• Polygenic risk modeling for prediction of epithelial ovarian cancer risk

  2022influential reference
• Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline.

  2022cited by this paper
• First‐ and second‐degree family history of ovarian and breast cancer in relation to risk of invasive ovarian cancer in African American and white women

  2021cited by this paper
• Risk-Reducing Bilateral Salpingo-Oophorectomy for Ovarian Cancer: A Review and Clinical Guide for Hereditary Predisposition Genes.

  2021cited by this paper
• Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial

  2021cited by this paper
• A comparison of ovarian cancer mortality in women with BRCA1 mutations undergoing annual ultrasound screening or preventive oophorectomy.

  2019influential reference
• Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement

  2018cited by this paper
• Ovarian cancer: epidemiology and risk factors.

  2017cited by this paper
• Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction.

  2017cited by this paper
• Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk – Combined Results from Two Screening Trials

  2017cited by this paper
• Net reclassification index at event rate: properties and relationships

  2017cited by this paper
• Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium.

  2016cited by this paper
• Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci.

  2016cited by this paper
• Origin, Methods, and Evolution of the Three Nurses' Health Studies.

  2016cited by this paper
• An epidemiologic risk prediction model for ovarian cancer in Europe: the EPIC study

  2015cited by this paper
• A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects

  2015cited by this paper
• Net reclassification indices for evaluating risk prediction instruments: a critical review.

  2014cited by this paper
• Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants

  2013cited by this paper
• Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information

  2010cited by this paper
• Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.

  2009cited by this paper
• Cancer prevention research

  2008cited by this paper
• The Nurses' Health Study: lifestyle and health among women

  2005cited by this paper
• Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.

  2000cited by this paper
• Estrogens, progestins and breast cancer risk in post-menopausal women: state of the ongoing controversy in 1992.

  1992cited by this paper
• Floating absolute risk: an alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference group.

  1991cited by this paper
• Projecting individualized probabilities of developing breast cancer for white females who are being examined annually.

  1989influential reference
• Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.

  1988cited by this paper
• The meaning and use of the area under a receiver operating characteristic (ROC) curve.

  1982cited by this paper

• No citing papers are available for this paper.