SCIENCE@home

Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy

Laura F Heidiri,Silke Ethofer,Georgios Naros,Frank J. van Schalkwijk,R. Helfrich

Published 2025 in Journal of Neuroscience

ABSTRACT

Epilepsy constitutes a clinically manifest excitability disorder that is characterized by aberrant electrophysiological activity in the electroencephalogram (EEG). The correct identification of the seizure onset zone relies on the visual detection of pathological waveforms and the assessment of their morphology, rhythmicity, and density. Recent advances in quantitative EEG analyses indicated that aperiodic EEG background activity might provide complementary information to traditional qualitative methods. Importantly, aperiodic activity, and specifically the slope of the 1/ƒχ decay function of the power spectrum, might constitute a biomarker of the underlying population excitability dynamics. Hence, in the context of epileptic activity, an altered spectral slope is often considered as a signature of pathological excitability. To date, it remained unclear if this straightforward interpretation also applies to states of manifest seizure activity. To address this question, we recorded intracranial electroencephalography (iEEG) during focal seizures from patients diagnosed with pharmacoresistant epilepsy (18 patients, 11 females). The results demonstrate that the spectral slope successfully delineates seizure activity. However, the spectral slope was sensitive to the presence and waveform shape of distinct epileptic components. By combining iEEG recordings with simulations, we demonstrate that epileptic spiking activity and associated slow-wave components differentially impact spectral slope estimates. These results offer a more parsimonious explanation for the biophysical origins of aperiodic activity as compared with the concept of an underlying balance between excitation and inhibition.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-58 of 58 references · Page 1 of 1

CITED BY

  • No citing papers are available for this paper.

Showing 0-0 of 0 citing papers · Page 1 of 1