Golgi‐Targeted Viscosity Fluorescent Probe for Monitoring Acute Lung Injury

Abstract Acute lung injury (ALI) is a severe respiratory disorder driven by uncontrolled inflammation, where early diagnosis and intervention are critical. Recent evidence implicates Golgi apparatus dysfunction in ALI progression, but its biophysical changes remain unexplored. Here, we report GV, a novel Golgi‐targeted fluorescent probe with high photostability, low cytotoxicity, and excellent specificity, enabling sensitive imaging of viscosity changes under stress. Using both cellular and mouse models of ALI, we demonstrated a significant increase in Golgi viscosity during disease progression. These findings suggest that Golgi viscosity may serve as a potential biomarker for ALI and establish GV as a powerful tool for investigating organelle‐level biophysical alterations in inflammatory diseases.

• Publication year

  2025

• Venue

  Chemistry

• Publication date

  2025-11-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/chem.202502835PMID 41215608PMCID 12712764
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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