The Longitudinal Reciprocal Relations of Adolescents' Non-Suicidal Self-Injury and Suicidal Ideation and the Mediating Role of Irritability: A Random Intercept Cross-Lagged Panel Model Analysis.

Xin Han,Chuhan Wang,Zixi Huang,Jinglei Wu,Xiaohe Li,Jianing You

Published 2025 in Suicide and Life-Threatening Behaviour

ABSTRACT

BACKGROUND In recent years, the prevalence of non-suicidal self-injury (NSSI) and suicidal ideation (SI) has been continuously increasing among adolescents, making it a global public health concern. While previous studies have identified a close relationship between NSSI and SI, few have delved into their reciprocal relationship and the underlying mechanisms. AIMS This study aimed to examine the longitudinal relation between NSSI and SI, and the mediating role of irritability in the bidirectional association. MATERIALS AND METHODS This study used the Brief Irritability Test (BIT), the Deliberate Self- Harm Inventory (DSHI), and the Beck Scale for Suicidal Ideation Chinese version (BSICV) in a three-wave longitudinal survey among 1711 Chinese adolescents (MAge = 14.44 years, SD = 1.35; 54.7% females), with 6-month intervals. Data were analyzed by using the random intercept cross-lagged panel model (RI-CLPM). RESULTS The results revealed that: (1) At the between-person level, NSSI, irritability, and SI were all positively associated with one another. (2) Greater within-person NSSI predicted future greater SI and vice versa. (3) Greater within-person irritability predicted future greater SI and NSSI, and vice versa. (4) Irritability acted as a mediator in the bidirectional relations between NSSI and SI. DISCUSSION The study proposed a dynamic and integrative perspective on the longitudinal relation among NSSI, irritability, and SI, emphasizing the evolving nature of these reciprocal relationships. CONCLUSION These findings underscore the importance of addressing irritability in adolescents and highlight the need to enhance adolescents' emotional regulation skills to effectively mitigate the risk of NSSI and SI.

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