Spatially Extensive LFP Correlations Identify Slow-Wave Sleep in Marmoset Sensorimotor Cortex

Identifying neural signatures of slow-wave sleep (SWS) is important for a number of reasons including diagnosing potential sleep disorders and examining its role in memory consolidation ( Diekelmann and Born, 2010; Klinzing et al., 2019; Brodt et al., 2023). Studies of sleep in the common marmoset (Callithrix jacchus) have revealed similarities to humans and other nonhuman primates, including distinct sleep stages ( Crofts et al., 2001) and diurnal sleep patterns ( Hoffmann et al., 2012). Advances in applying wireless technology for recording neural activity during natural, unrestrained behaviors ( Walker et al., 2021) position the marmoset as an excellent model for studying sleep-related neural activity associated with learning. Here, we identify putative SWS epochs based on the spatially correlated activity of local field potentials (LFPs) recorded from a multielectrode planar array implanted in the sensorimotor cortex of two marmosets (one female and one male). The average correlation of the LFP signal measured between electrodes decreased gradually with the distance between pairs. We modeled this spatial structure as an exponential decay function, where the spatial decay constant varied significantly over time, reaching its lowest values during epochs where LFP power dynamics were consistent with SWS. These periods of widespread high correlations across the sensorimotor cortex closely matched SWS identification commonly used in rodent models based on the changes in power in the gamma (30–60 Hz) and delta/slow oscillation (0.1–4 Hz) frequency bands. These findings demonstrate that putative SWS epochs can be reliably identified using spatially correlated LFP activity across the sensorimotor cortex.

• Publication year

  2025

• Venue

  eNeuro

• Publication date

  2025-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/ENEURO.0139-25.2025PMID 41213808PMCID 12604550
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The predictive value for performance speed of preparatory changes in neuronal activity of the monkey motor and premotor cortex.

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• Making arm movements within different parts of space: the premotor and motor cortical representation of a coordinate system for reaching to visual targets

  1991cited by this paper
• Spontaneous Discharge of Single Neurons during Sleep and Waking

  1962cited by this paper
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  1915influential reference

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