SOX2 phosphorylation during mitosis limits genomic damage

In this study, Williams et al. uncover a phosphorylation-based regulatory switch that controls SOX2's chromatin binding specificity and its pioneer activity in dividing neural stem cells. This mechanism is found to be critical for maintaining genomic integrity during mitosis, alluding to the oncogenic consequences of excessive pioneer function when SOX2 is misregulated.

• Publication year

  2025

• Venue

  Genes & Development

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.352664.125PMID 41213799PMCID 12863253
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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