Role of the Choroid Plexus Kir7.1 Channel in the Regulation of Mouse Cerebrospinal Fluid K+ Concentration

K+ channel Kir7.1 is prominently expressed at the apical membrane of the choroid plexus epithelium (CPE) together with the Na+‐K+‐ATPase pump and cotransporter NKCC1. Its unusual independence of extracellular K+ ([K+]o) suggests a key role in regulating cerebrospinal fluid (CSF) K+ concentration ([K+]CSF). We tested this hypothesis by exploring the effect of Kir7.1 inactivation or modification of its K+‐dependence in mice.

• Publication year

  2025

• Venue

  Acta Physiologica

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/apha.70129PMID 41212743
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target

  2025cited by this paper
• Normal vision and development in mice with low functional expression of Kir7.1 in heterozygosis for a blindness-producing mutation inactivating the channel.

  2024cited by this paper
• Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus.

  2023cited by this paper
• Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1

  2023cited by this paper
• The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus.

  2023influential reference
• Dual function of the choroid plexus: Cerebrospinal fluid production and control of brain ion homeostasis.

  2023cited by this paper
• Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain

  2023cited by this paper
• Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

  2022cited by this paper
• Choroid plexus epithelium and its role in neurological diseases

  2022cited by this paper
• Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

  2022cited by this paper
• Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

  2022cited by this paper
• Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus

  2022cited by this paper
• Multiple Na,K-ATPase Subunits Colocalize in the Brush Border of Mouse Choroid Plexus Epithelial Cells

  2021cited by this paper
• Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

  2021cited by this paper
• Molecular mechanisms of brain water transport

  2021cited by this paper
• Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter.

  2019cited by this paper
• The choroid plexus sodium‐bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH

  2018cited by this paper
• Cotransporter-mediated water transport underlying cerebrospinal fluid formation

  2018cited by this paper
• Tissue Distribution of Kir7.1 Inwardly Rectifying K+ Channel Probed in a Knock-in Mouse Expressing a Haemagglutinin-Tagged Protein

  2018cited by this paper
• Fluid and ion transfer across the blood–brain and blood–cerebrospinal fluid barriers; a comparative account of mechanisms and roles

  2016cited by this paper
• ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels.

  2016cited by this paper
• The inner CSF–brain barrier: developmentally controlled access to the brain via intercellular junctions

  2015cited by this paper
• Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

  2015cited by this paper
• Contributions of the Na+/K+‐ATPase, NKCC1, and Kir4.1 to hippocampal K+ clearance and volume responses

  2014influential reference
• Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1

  2014cited by this paper
• Cerebrospinal fluid secretion by the choroid plexus.

  2013cited by this paper
• KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium

  2011influential reference
• Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.

  2010cited by this paper
• Water-Transporting Proteins

  2010cited by this paper
• Inwardly rectifying potassium channels: their structure, function, and physiological roles.

  2010cited by this paper
• NBCe2 exhibits a 3 HCO3(-):1 Na+ stoichiometry in mouse choroid plexus epithelial cells.

  2008cited by this paper
• Simultaneous measurement of water volume and pH in single cells using BCECF and fluorescence imaging microscopy.

  2006cited by this paper
• Distribution of sodium transporters and aquaporin‐1 in the human choroid plexus

  2006cited by this paper
• Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1

  2005cited by this paper
• Epithelial potassium transport: Tracer and electrophysiological studies in choroid plexus

  2005influential reference
• The retinal pigment epithelium in visual function.

  2005cited by this paper
• Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells.

  2004influential reference
• Expression and permeation properties of the K+ channel Kir7.1 in the retinal pigment epithelium

  2001cited by this paper
• Stable cation coordination at a single outer pore residue defines permeation properties in Kir channels

  2000cited by this paper
• Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase.

  1999cited by this paper
• Cloning and characterization of a novel human inwardly rectifying potassium channel predominantly expressed in small intestine

  1998cited by this paper
• A Novel Inward Rectifier K 1 Channel with Unique Pore Properties

  1998cited by this paper
• The Epithelial Inward Rectifier Channel Kir7.1 Displays Unusual K+ Permeation Properties

  1998influential reference
• Functional demonstration of Na+-K+-2Cl-cotransporter activity in isolated, polarized choroid plexus cells.

  1998cited by this paper
• Exaggerated urinary excretion of aquaporin-2 in the pathological state of impaired water excretion dependent upon arginine vasopressin.

  1998cited by this paper
• [19] Use of ion-selective microelectrodes andfluorescent probes to measure cell volume

  1995cited by this paper
• Evidence for two types of potassium current in rat choroid plexus epithelial cells

  1994cited by this paper
• Potassium cotransport at the rat choroid plexus.

  1994cited by this paper
• Response of infant and adult rat choroid plexus potassium transporters to increased extracellular potassium.

  1991cited by this paper
• The control of potassium concentration in the cerebrospinal fluid and brain interstitial fluid of developing rats.

  1987cited by this paper
• Maintenance of a constant brain extracellular potassium.

  1976cited by this paper
• Efflux mechanism contributing to the stability of the potassium concentration in cerebrospinal fluid

  1970cited by this paper

• Physiology of K+ Homeostasis in Cerebrospinal Fluid: The Fine‐Tuning Role of the Choroid Plexus Kir7.1 Channel

  2025cites this paper