Sevoflurane and Desflurane Spin–Decoherence Effect on Fe(III)acetylacetonate Redox Process

This study investigates the influence of sevoflurane and desflurane on the electrochemical behavior of the Fe(III)-acetylacetonate (Fe(acac)3) complex. Using cyclic voltammetry (CV), we demonstrate that while Fe(acac)3 exhibits reversible redox behavior in an oxygen-free environment, the presence of dissolved oxygen renders the system irreversible, leading to the formation of a thick, reddish film on the electrode surface upon potential cycling. Notably, the addition of sevoflurane and desflurane restores the electrochemical reversibility and dramatically inhibits this film formation. Raman spectroscopy of the resulting films confirmed structural changes which are consistent with this inhibiting action. Furthermore, X-ray photoelectron spectroscopy (XPS) analysis reveals that the iron in the film remains predominantly in the Fe3+ oxidation state even after prolonged electrochemical reduction cycles. These findings suggest that the anesthetics act by inhibiting the interaction between the Fe(acac)3 complex and oxygen, likely through a spin–decoherence mechanism. This work highlights the critical role of anesthetics in modifying the electrochemical behavior of metal-oxygen complexes, with potential implications for sensing, electrocatalysis, and bio-oriented systems.

• Publication year

  2025

• Venue

  Molecules

• Publication date

  2025-11-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3390/molecules30224341PMID 41302401PMCID 12654998
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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