A gut microbial metabolite of ginsenosides, compound K, induces intestinal glucose absorption and Na(+) /glucose cotransporter 1 gene expression through activation of cAMP response element binding protein.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Molecular Nutrition & Food Research

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mnfr.201400688PMID 25600494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation

  2014cited by this paper
• Ginsenoside Metabolite Compound K Promotes Recovery of Dextran Sulfate Sodium-Induced Colitis and Inhibits Inflammatory Responses by Suppressing NF-κB Activation

  2014cited by this paper
• Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus.

  2014cited by this paper
• Panax red ginseng extract regulates energy expenditures by modulating PKA dependent lipid mobilization in adipose tissue.

  2014cited by this paper
• Comparative Analysis of the Gut Microbiota in People with Different Levels of Ginsenoside Rb1 Degradation to Compound K

  2013cited by this paper
• Compound K, a final intestinal metabolite of ginsenosides, enhances insulin secretion in MIN6 pancreatic β-cells by upregulation of GLUT2.

  2013cited by this paper
• CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer’s disease

  2013cited by this paper
• Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells

  2013cited by this paper
• Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes.

  2013cited by this paper
• Regulation of Glucose Transporter Expression in Human Intestinal Caco-2 Cells following Exposure to an Anthocyanin-Rich Berry Extract

  2013cited by this paper
• HER-2/neu-mediated Down-regulation of Biglycan Associated with Altered Growth Properties*

  2012cited by this paper
• Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis.

  2012cited by this paper
• Regulation of SGLT expression and localization through Epac/PKA-dependent caveolin-1 and F-actin activation in renal proximal tubule cells.

  2012cited by this paper
• Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio.

  2012cited by this paper
• PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

  2011cited by this paper
• Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation.

  2011cited by this paper
• Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota

  2011cited by this paper
• CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

  2011cited by this paper
• Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

  2011cited by this paper
• Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes.

  2010cited by this paper
• Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation.

  2010cited by this paper
• Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt

  2010cited by this paper
• Variation in the gut microbiota of laboratory mice is related to both genetic and environmental factors.

  2010cited by this paper
• Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

  2009cited by this paper
• Determination of enriched histone modifications in non-genic portions of the human genome

  2009cited by this paper
• Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells.

  2009cited by this paper
• Sodium-Dependent Glucose Transporter-1 as a Novel Immunological Player in the Intestinal Mucosa1

  2008cited by this paper
• Lipopolysaccharide Induces Inhibition of Galactose Intestinal Transport in Rabbits in vitro

  2008cited by this paper
• Role of Sp1 and HNF1 transcription factors in SGLT1 regulation during chronic intestinal inflammation.

  2008cited by this paper
• Survival of cancer cells is maintained by EGFR independent of its kinase activity.

  2008cited by this paper
• Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides

  2007cited by this paper
• Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.

  2007cited by this paper
• The landscape of histone modifications across 1% of the human genome in five human cell lines.

  2007cited by this paper
• The GLUT4 glucose transporter.

  2007cited by this paper
• EGF–ERBB signalling: towards the systems level

  2006cited by this paper
• Ligand-independent activation of the EGFR by lipid raft disruption.

  2006cited by this paper
• Intestinal sugar transport.

  2006cited by this paper
• LPS/CD14 activation triggers SGLT-1-mediated glucose uptake and cell rescue in intestinal epithelial cells via early apoptotic signals upstream of caspase-3.

  2006cited by this paper
• Protein kinase C-α mediates epidermal growth factor receptor transactivation in human prostate cancer cells

  2005cited by this paper
• Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells.

  2005cited by this paper
• Hepatoprotective effect of ginsenoside Rb1 and compound K on tert‐butyl hydroperoxide‐induced liver injury

  2005cited by this paper
• Developmental decrease in rat small intestinal creatine uptake.

  2005cited by this paper
• Proximal Events in Signaling by Plasma Membrane Estrogen Receptors*

  2003cited by this paper
• Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins

  2003cited by this paper
• Ginsenoside-Rb1 acts as a weak phytoestrogen in MCF-7 human breast cancer cells

  2003cited by this paper
• Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor.

  2003cited by this paper
• The biological action of saponins in animal systems: a review.

  2002cited by this paper
• HuR binds a cyclic nucleotide‐dependent, stabilizing domain in the 3′ untranslated region of Na+/glucose cotransporter (SGLT1) mRNA

  2001cited by this paper
• Transcriptional regulation by the phosphorylation-dependent factor CREB

  2001cited by this paper
• Differential regulation of placental and germ cell alkaline phosphatases by glucocorticoid and sodium butyrate in human gastric carcinoma cell line TMK-1.

  2001cited by this paper
• Physical association between the histone acetyl transferase CBP and a histone methyl transferase

  2001cited by this paper
• Regulation of the human Na(+)-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1.

  2000cited by this paper
• Nuclear Organization of Mammalian Genomes

  1999cited by this paper
• I. Glucose galactose malabsorption.

  1998cited by this paper
• Thyroid hormone regulation of the Na+/glucose cotransporter SGLT1 in Caco-2 cells.

  1998cited by this paper
• Epidermal growth factor up-regulates sodium-glucose cotransport in enterocyte models in the presence of cholera toxin.

  1997cited by this paper
• 'Active' sugar transport in eukaryotes.

  1994cited by this paper
• The absorption and secretion of water and electrolytes across the healthy and the diseased human colonic mucosa measured in vitro

  1972cited by this paper
• Jejunal absorption of water and electrolytes in inflammatory bowel disease.

  1970cited by this paper

• Mechanistic insights into the regulation of glucose‒lipid metabolism by the bioactive constituents of ginseng.

  2025cites this paper
• Metformin Inhibits NLRP3 Inflammasome Expression and Regulates Inflammatory Microenvironment to Delay the Progression of Colorectal Cancer.

  2024cites this paper
• Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques

  2024cites this paper
• Hypoglycemic effects of mountain caviar extract and inhibitory mechanism of saponins, including momordin Ic, on glucose absorption

  2024cites this paper
• Glucocorticoid receptors involved in ginsenoside compound K ameliorate adjuvant arthritis by inhibiting the glycolysis of fibroblast-like synoviocytes via the NF-κB/HIF-1α pathway

  2023cites this paper
• Panax notoginseng-microbiota interactions: From plant cultivation to medicinal application.

  2023cites this paper
• Wuzang Wenyang Huayu Tang Promoting Learning-memory Ability in Vascular Dementia Rats via Brain-gut-microbiome Axis

  2023cites this paper
• Ginsenoside Compound K Ameliorates Development of Diabetic Kidney Disease through Inhibiting TLR4 Activation Induced by Microbially Produced Imidazole Propionate

  2022cites this paper
• Dietary phytochemicals that influence gut microbiota: Roles and actions as anti-Alzheimer agents

  2021cites this paper
• Preparative separation of gypenoside XVII, ginsenoside Rd2, notoginsenosides Fe and Fd from Panax notoginseng leaves by counter-current chromatography and orthogonality evaluation for the separation of four saponins.

  2021cites this paper
• Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting Activities

  2020influential citation
• Therapeutic potential of ginsenosides on diabetes: From hypoglycemic mechanism to clinical trials

  2020cites this paper
• Investigation of Absorption, Metabolism and Toxicity of Ginsenosides compound K Based on Human Organ Chips.

  2020cites this paper
• Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects.

  2019cites this paper
• CMAR_A_195424 3171..3185

  2019cites this paper
• 20(S)-Protopanaxadiol blocks cell cycle progression by targeting epidermal growth factor receptor.

  2019cites this paper
• Microbial Metabolites Determine Host Health and the Status of Some Diseases

  2019cites this paper
• High-density immobilization of a ginsenoside-transforming β-glucosidase for enhanced food-grade production of minor ginsenosides

  2019cites this paper
• SLC5A1 promotes growth and proliferation of pancreatic carcinoma via glucose-dependent AMPK/mTOR signaling

  2019cites this paper
• Saponins regulate intestinal inflammation in colon cancer and IBD.

  2019cites this paper
• Ginsenoside 25-OCH3-PPD Promotes Activity of LXRs To Ameliorate P2X7R-Mediated NLRP3 Inflammasome in the Development of Hepatic Fibrosis.

  2018cites this paper
• Connection between Systemic Inflammation and Neuroinflammation Underlies Neuroprotective Mechanism of Several Phytochemicals in Neurodegenerative Diseases

  2018cites this paper
• An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression

  2015influential citation