Cytokine–Cytokine Receptor Interaction and Endocytosis are Common Pathways for Symptom Burden and Sickness Behavior Symptoms in Oncology Patients Undergoing Chemotherapy

C. Harris,K. Kober,Joosun Shin,L. Morse,K. Oppegaard,Steven M. Paul,Marilyn J. Hammer,J. Levine,Yvette P. Conley,C. Miaskowski

Published 2025 in Cancer Medicine

ABSTRACT

Inflammation is associated with sickness behavior symptoms in patients receiving chemotherapy. However, its impact on symptom burden (i.e., higher number of concurrent symptoms) requires evaluation. Study purposes were to evaluate for differentially perturbed immune and/or inflammatory pathways between outpatients receiving chemotherapy with Low (i.e., 0–8) versus High (i.e., 16–38) symptom burden and identify common immune and/or inflammatory pathways among symptom burden and single sickness behavior symptoms.

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