Depression in Premanifest Huntington's Disease: Aberrant Effective Connectivity of Striatum and Default Mode Network

Tamrin Barta,Leonardo Novelli,N. Georgiou‐Karistianis,Julie C. Stout,Samantha M Loi,Y. Glikmann-Johnston,A. Razi

Published 2025 in Movement Disorders

ABSTRACT

Depression frequently precedes motor symptoms in Huntington's disease gene expansion carriers (HDGECs), yet the neural mechanisms remain poorly characterized.

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