Association of BDNF Val66Met genotype with obesity indicators and metabolic parameters

Abstract The aim of this study was to investigate the association of BDNF Val66Met genotype with obesity markers and metabolic parameters in a Turkish population. The study data were collected with a questionnaire form. The questionnaire form included general information, anthropometric measurements, dietary intake, lifestyle factors and biochemical parameters. Genotyping of the Val66Met variant in the BDNF gene was performed by real-time polymerase chain reaction (PCR). Individuals with the AG+AA genotype showed differences in obesity and metabolic parameters compared to GG homozygotes. Additionally, individuals with the AG+AA genotype showed lower waist circumference (pinteraction = 0.04), waist-to-hip ratio (pinteraction = 0.003), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR; pinteraction = 0.009) when consuming a high-fibre diet (>18 g/day) compared to GG homozygotes. The study highlights the influence of BDNF Val66Met genotype on obesity and metabolic parameters, with dietary fibre intake potentially modifying these effects.

• Publication year

  2025

• Venue

  International Journal of Food Science and Nutrition

• Publication date

  2025-11-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/09637486.2025.2584321PMID 41221641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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