MTA1 upregulation enhances stemness and chemoresistance of gastric cancer cells

Highlights • MTA1 is significantly upregulated in gastric cancer tissues and AGS cells.• MTA1 enhances chemoresistance to doxorubicin and cisplatin by increasing IC50 values.• MTA1 promotes cancer cell stemness by upregulating SOX-2 and OCT-4 expression.• MTA1 suppresses apoptosis by modulating Bax and Bcl-2 expression.• Targeting MTA1 may offer a novel therapeutic strategy for overcoming chemoresistance in gastric cancer.

• Publication year

  2025

• Venue

  Translational Oncology

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.tranon.2025.102583PMID 41218552PMCID 12648086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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