The Effect of Postexposure Sleep Deprivation on Anxiety-Related Behaviours and Hippocampal Neuropathological Changes in a Rat Model of Posttraumatic Stress Disorder.

Sleep problems are a hallmark of posttraumatic stress disorder (PTSD). Although the critical role of sleep for memory consolidation is well known, there is no consensus on the effect of sleep interruption or increased sleep duration immediately after a traumatic experience on the development of PTSD. In addition, the effect of the loss of specific sleep stages postexposure on the development of PTSD is not fully elucidated. Using the single prolonged stress (SPS) procedure, we aimed to determine the effect of postexposure REM sleep deprivation (REMSD) or total sleep deprivation (TSD) on memory function, anxiety-related behaviours and related biochemical parameters. Fear and anxiety-like behaviour, hippocampal BDNF and acetylcholinesterase (AChE) levels in animals exposed to SPS alone or to the combination of SPS + REMSD or SPS + TSD were tested against a group of unexposed control animals. In our study, we found that SPS rats had impaired memory formation and performed poorly on anxiety-related behaviours. The effects of REMSD or TSD on anxiety-related behaviours after SPS were similar and did not result in a significant improvement. Furthermore, posttraumatic TSD further reduced the SPS-induced decrease in hippocampal BDNF expression, while it also increased hippocampal AChE levels to a similar extent. These findings underscore the importance of sleep as a focus for ongoing research into the pathogenesis of PTSD, and the fact that eliminating specific REM or total sleep immediately after trauma exposure has limited effects on the development of PTSD.

• Publication year

  2025

• Venue

  International Journal of Developmental Neuroscience

• Publication date

  2025-11-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/jdn.70066PMID 41218983
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice

  2024cited by this paper
• The potential beneficial effect of sleep deprivation following traumatic events to preventing PTSD: Review of current insight regarding sleep, memory, and trauma resonating with ancient rituals—Àìsùn Oku (African) and Tsuya (Japanese)

  2023cited by this paper
• FGF-18 alleviates memory impairments and neuropathological changes in a rat model of Alzheimer's disease.

  2023cited by this paper
• To sleep or not to sleep, that is the question: A systematic review and meta-analysis on the effect of post-trauma sleep on intrusive memories of analog trauma.

  2023cited by this paper
• Instantaneous antidepressant effect of lateral habenula deep brain stimulation in rats studied with functional MRI

  2023cited by this paper
• Galium aparineL. protects against acetaminophen-induced hepatotoxicity in rats.

  2022cited by this paper
• Protective effects of lamotrigine and vitamin B12 on pentylenetetrazole-induced epileptogenesis in rats.

  2021cited by this paper
• The Many Faces of Sleep Disorders in Post-Traumatic Stress Disorder: An Update on Clinical Features and Treatment

  2021cited by this paper
• Sleep parameters improvement in PTSD soldiers after symptoms remission

  2021cited by this paper
• Sodium butyrate enhances fear extinction and rescues hippocampal acetylcholinesterase activity in a rat model of posttraumatic stress disorder

  2021cited by this paper
• Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs

  2021cited by this paper
• Disturbed Sleep in PTSD: Thinking Beyond Nightmares

  2021cited by this paper
• Translational relevance of behavioral, neural, and electroencephalographic profiles in a mouse model of post-traumatic stress disorder

  2021cited by this paper
• Rodent models of post-traumatic stress disorder: behavioral assessment

  2020cited by this paper
• Optogenetic sleep enhancement improves fear-associated memory processing following trauma exposure in rats

  2020cited by this paper
• Short-term sleep deprivation immediately after contextual conditioning inhibits BDNF signaling and disrupts memory consolidation in predator odor trauma mice model of PSTD.

  2020cited by this paper
• Sleep in posttraumatic stress disorder: A systematic review and meta-analysis of polysomnographic findings.

  2019cited by this paper
• Effects of post‐learning REM sleep deprivation on hippocampal plasticity‐related genes and microRNA in mice

  2019cited by this paper
• The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression

  2019cited by this paper
• Neurochemical mechanisms for memory processing during sleep: basic findings in humans and neuropsychiatric implications

  2019cited by this paper
• Sleep and intrusive memories immediately after a traumatic event in emergency department patients

  2019cited by this paper
• Trauma associated sleep disorder: A parasomnia induced by trauma.

  2018cited by this paper
• Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder

  2018cited by this paper
• Preventing sleep on the first resting phase following a traumatic event attenuates anxiety‐related responses

  2017cited by this paper
• Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic‐pituitary‐adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis – related proteins in a rat model of post‐traumatic stress disorder

  2017cited by this paper
• Posttraumatic stress disorder in the World Mental Health Surveys

  2017cited by this paper
• Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1.

  2016cited by this paper
• Sleep and mental disorders: A meta-analysis of polysomnographic research.

  2016cited by this paper
• Sleep disorders in combat-related PTSD

  2015cited by this paper
• Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD

  2014cited by this paper
• Intra-hippocampal administration of ZIP alleviates depressive and anxiety-like responses in an animal model of posttraumatic stress disorder

  2014cited by this paper
• Sleep, plasticity and memory from molecules to whole-brain networks.

  2013cited by this paper
• Posttraumatic stress disorder exacerbation with cholinesterase inhibitor in a patient with dementia.

  2013cited by this paper
• About sleep's role in memory.

  2013cited by this paper
• Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

  2012cited by this paper
• Post-Exposure Sleep Deprivation Facilitates Correctly Timed Interactions Between Glucocorticoid and Adrenergic Systems, which Attenuate Traumatic Stress Responses

  2012cited by this paper
• Stress-induced altered cholinergic-glutamatergic interactions in the mouse hippocampus.

  2012cited by this paper
• Linearization of the bradford protein assay.

  2010cited by this paper
• Sleep deprivation facilitates extinction of implicit fear generalization and physiological response to fear.

  2010cited by this paper
• Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder.

  2009cited by this paper
• Pharmacotherapy of PTSD: premises, principles, and priorities.

  2009cited by this paper
• Polysomnographically measured sleep abnormalities in PTSD: a meta-analytic review.

  2007cited by this paper
• Posttraumatic stress disorder-like symptoms after treatment with acetylcholinesterase inhibitors.

  2007cited by this paper
• Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning.

  2003cited by this paper
• Downregulation of BDNF mRNA in the Hippocampal Dentate Gyrus after Re-exposure to Cues Previously Associated with Footshock

  2002cited by this paper
• Synaptic plasticity and mood disorders

  2002cited by this paper
• Differential effect of short-term REM sleep deprivation on NGF and BDNF protein levels in the rat brain.

  2000cited by this paper
• Contextual fear conditioning is associated with an increase of acetylcholine release in the hippocampus of rat.

  2000cited by this paper
• Acute stress facilitates long-lasting changes in cholinergic gene expression

  1998cited by this paper
• Stress-restress: effects on ACTH and fast feedback.

  1997cited by this paper
• In Vivo Hippocampal Acetylcholine Release During Exposure to Acute Stress.

  1997cited by this paper
• Scopolamine administered before and after training impairs both contextual and auditory-cue fear conditioning.

  1996cited by this paper

• No citing papers are available for this paper.