The OSMAC strategy unveils new naphthopyranon and diverse bioactive metabolites from termite‐associated Aspergillus chevalieri BYST01

Despite the revelation of numerous uncharacterized biosynthetic gene clusters (BGCs) in the termite‐associated fungus Aspergillus chevalieri BYST01 through genome mining, no suitable culture conditions have been established to activate the production of new secondary metabolites.

• Publication year

  2025

• Venue

  Pest Management Science

• Publication date

  2025-11-11

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/ps.70356PMID 41220195
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mining Silent Biosynthetic Gene Clusters for Natural Products in Filamentous Fungi

  2025cited by this paper
• A combination of genome mining with OSMAC strategy facilitates the discovery of bioactive metabolites produced from termite-associated Streptomyces tanashiensis BYF-112.

  2025cited by this paper
• Design, Synthesis, Antibacterial Activity, and Antivirulence Factor of Novel 1,2,4-Thiadiazole Derivatives Containing an Amide Moiety.

  2025influential reference
• Chevalierlin: a spirocyclic alkaloid from a hydrothermal vent associated fungus Aspergillus chevalieri TW132-65.

  2024cited by this paper
• Discovering the hidden function in fungal genomes

  2024cited by this paper
• Design, Synthesis, and Herbicidal Activity of Natural Naphthoquinone Derivatives Containing Diaryl Ether Structures.

  2024cited by this paper
• Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290

  2024cited by this paper
• OSMAC Strategy: A promising way to explore microbial cyclic peptides.

  2024cited by this paper
• New bioactive secondary metabolites from fungi: 2023

  2024cited by this paper
• New Polyketide Congeners with Antibacterial Activities from an Endophytic Fungus Stemphylium globuliferum 17035 (China General Microbiological Culture Collection Center No. 40666)

  2024cited by this paper
• Plant secondary metabolites-mediated plant defense against bacteria and fungi pathogens.

  2024cited by this paper
• Genome mining for unknown–unknown natural products

  2023cited by this paper
• Biological Control of Wheat Powdery Mildew Disease by the Termite-associated Fungus Aspergillus chevalieri BYST01 and Potential Role of Secondary Metabolites.

  2023influential reference
• A review on nutritional and non-nutritional interactions of symbiotic and associated fungi with insect

  2023cited by this paper
• Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery.

  2023cited by this paper
• Identification of Obscurolide-Type Metabolites and Antifungal Metabolites from the Termite-Associated Streptomyces neopeptinius BYF101.

  2023cited by this paper
• Protective role of plant growth-promoting fungi Aspergillus chevalieri OP593083 and Aspergillus egyptiacus OP593080 as biocontrol approach against Alternaria leaf spot disease of Vicia faba plant

  2023cited by this paper
• Strategies for Natural Product Discovery by Unlocking Cryptic Biosynthetic Gene Clusters in Fungi

  2023cited by this paper
• Diversity, antibacterial and phytotoxic activities of culturable endophytic fungi from Pinellia pedatisecta and Pinellia ternata

  2023influential reference
• Kojicone C, new anti-inflammatory polyketide from insect-associated fungus Aspergillus versicolor

  2023cited by this paper
• Fermentation in Minimal Media and Fungal Elicitation Enhance Violacein and Deoxyviolacein Production in Two Janthinobacterium Strains

  2022cited by this paper
• A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79

  2022cited by this paper
• The numbers of fungi: are the most speciose genera truly diverse?

  2022cited by this paper
• Natural products and drug discovery

  2022cited by this paper
• Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins.

  2022cited by this paper
• Anti-Epstein-Barr Viral Agents from the Medicinal Herb-Derived Fungus Alternaria alstroemeriae Km2286.

  2022cited by this paper
• On the enzymes’ actions of entomopathogenic fungi against certain indigenous and invasive insect pests

  2021cited by this paper
• Comparison of Aspergillus chevalieri and related species in dark tea at different aspects: Morphology, enzyme activity and mitochondrial genome

  2021cited by this paper
• Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1

  2021cited by this paper
• The chemical diversity, the attractant, anti-acetylcholinesterase, and antifungal activities of metabolites from biocontrol Trichoderma harzianum uncovered by OSMAC strategy.

  2021cited by this paper
• Alkylated Salicylaldehydes and Prenylated Indole Alkaloids from the Endolichenic Fungus Aspergillus chevalieri and Their Bioactivities.

  2021cited by this paper
• Structure-based ligand design and discovery of novel tenuazonic acid derivatives with high herbicidal activity

  2021cited by this paper
• Two classic mutations in the linker-helix IIL45 and segment IIS6 of Apolygus lucorum sodium channel confer pyrethroid resistance.

  2020cited by this paper
• An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes

  2020cited by this paper
• New azaphilone, isocoumarin and α-pyrone derivatives from the marine-derived gut fungus Paraphaeosphaeria sp. XZD2-1

  2020cited by this paper
• Phenolic glucosides and chromane analogs from the insect fungus Conoideocrella krungchingensis BCC53666

  2019cited by this paper
• Novel 1,3,4-Oxadiazole Derivatives Containing a Cinnamic Acid Moiety as Potential Bactericide for Rice Bacterial Diseases

  2019influential reference
• Banksialactones and Banksiamarins: Isochromanones and Isocoumarins from an Australian Fungus, Aspergillus banksianus.

  2018cited by this paper
• Antibacterial Indole Alkaloids and Anthraquinones from a Sewage-Derived Fungus Eurotium sp.

  2018cited by this paper
• Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp. RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line

  2018influential reference
• Effects of minimal media vs. complex media on the metabolite profiles of Escherichia coli and Saccharomyces cerevisiae

  2017cited by this paper
• Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization

  2016cited by this paper
• Allelopathy and the active metabolites of the endophytic fungus, Alternaria J46, from Platycladus orientalis

  2015cited by this paper
• Fungal polyketide biosynthesis - a personal perspective.

  2014cited by this paper
• Antitubercular and Antibacterial Activity of Quinonoid Natural Products Against Multi‐Drug Resistant Clinical Isolates

  2014cited by this paper
• Isolation of talathermophilins from the thermophilic fungus Talaromyces thermophilus YM3-4.

  2011cited by this paper
• Benzyl derivatives with in vitro binding affinity for human opioid and cannabinoid receptors from the fungus Eurotium repens.

  2011cited by this paper
• Antibacterial properties of anthraquinones extracted from rhubarb against Aeromonas hydrophila

  2011cited by this paper
• Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity.

  2004cited by this paper
• Immunomodulatory constituents from an ascomycete, Microascus tardifaciens.

  1999cited by this paper
• Pigments of Fungi. XLVII. Cardinalic Acid, a New Anthraquinone Carboxylic Acid from the New Zealand Toadstool Dermocybe cardinalis and the Synthesis and X-Ray Crystal Structure of Methyl 1,7,8-Tri-O-methylcardinalate

  1998cited by this paper

• Antimicrobial metabolites of the intestinal fungus Trichoderma sp. QTYC44 from Pantala flavescens larvae

  2026cites this paper