Childhood adversity and spontaneous abortion in a north American preconception cohort study.

Childhood adversity has been associated with adverse adult health outcomes. We investigated its association with spontaneous abortion (SAB) risk and the potential buffering effects of social support and integration (SSI). This analysis included 6100 participants from Pregnancy Study Online, a North American preconception cohort study of females attempting spontaneous conception (2013-2024). We assessed childhood adversity via the Adverse Childhood Experiences (ACE) scale and Brief Trauma Questionnaire (BTQ), lifetime SSI via the Berkman-Syme Social Network Index, and pregnancy outcomes via follow-up questionnaires. We used Cox proportional hazards regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI), adjusted for potential confounders. Neither the ACE score nor individual ACE domains were appreciably associated with SAB risk. However, participants who reported childhood physical (HR = 1.11, 95% CI: 0.92-1.35), sexual (HR = 1.12, 95% CI:0.96-1.30), or both abuse types (HR = 1.09, 95% CI:0.90-1.32) on the BTQ had slightly increased SAB risk compared with those who reported no abuse. Associations were stronger among participants who reported lower childhood SSI (physical and sexual abuse vs. no abuse: HR = 1.76, 95% CI:1.15-2.68). These findings indicate that BTQ-ascertained physical and sexual abuse may be associated with SAB risk among those with lower childhood SSI.

• Publication year

  2025

• Venue

  American Journal of Epidemiology

• Publication date

  2025-11-12

• Fields of study

  Medicine, Sociology, Psychology

• Identifiers
  DOI 10.1093/aje/kwaf246PMID 41222293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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