The impact of genetic susceptibility and the role of aging acceleration in the association of urinary zinc with lung function decline: A repeated-measures study.

BACKGROUND Zinc pollution is alarming, demanding urgent attention to its adverse effects. METHODS The prospective study was conducted among 10057 general Chinese observations from the Wuhan-Zhuhai cohort. Genetic susceptibility was assessed by calculating the lung function-related polygenic risk score (PRS). Aging acceleration of Klemera-Doubal age (KDM_AA) and phenotypic age (PHE_AA) were constructed from clinical parameters. The associations between urinary zinc and lung function were assessed using group-based trajectory models and linear mixed models (LMMs). The relationships of urinary zinc with KDM_AA and PHE_AA were evaluated using LMMs, and the mediating role of aging acceleration was assessed via longitudinal mediation analyses. RESULTS Urinary zinc was negatively associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), especially in the third PRS quantile group. Each 1-unit increase in ln-transformed value of urinary zinc was associated with the annual change rate in FVC and FEV1 of -10.624 (95 % confidence interval -17.617, -3.550) mL/year and -6.826 (-12.113, -1.469) mL/year, respectively. Positive longitudinal associations were observed between urinary zinc and aging acceleration, with the annual change rate of 0.128 (0.038, 0.219) years/year for KDM_AA and 0.077 (0.036, 0.118) years/year for PHE_AA. Moreover, aging acceleration partially mediated the associations of urinary zinc with FVC and FEV1, and the mediated proportion ranged from 11.38 % to 18.60 %. CONCLUSIONS Zinc exposure was associated with lung function decline especially among individuals genetically vulnerable. Biological aging acceleration caused by zinc exposure may be the potential mechanism.

• Publication year

  2025

• Venue

  Ecotoxicology and Environmental Safety

• Publication date

  2025-11-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.ecoenv.2025.119379PMID 41218489
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Urinary trace elements and thyroid nodule formation in a longitudinal cohort of older women: Findings from KoGES.

  2025cited by this paper
• Mechanisms and markers of lung ageing in health and disease

  2025cited by this paper
• ERJ advances: epigenetic ageing and leveraging DNA methylation in chronic respiratory diseases

  2024cited by this paper
• Lifestyles and their relative contribution to biological aging across multiple organ systems: change analysis from the China Multi-Ethnic Cohort Study

  2024cited by this paper
• Elevated vesicular Zn2+ in dorsal root ganglion neurons expressing the transporter TMEM163 causes age-associated itchy skin in mice

  2024cited by this paper
• Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

  2023cited by this paper
• DNA methylation aging signatures of multiple metals exposure and their mediation effects in metal-associated mortality: Evidence from the Dongfeng-Tongji cohort study.

  2023cited by this paper
• Longitudinal association of polycyclic aromatic hydrocarbons and genetic risk with lung function.

  2023cited by this paper
• Depressive Symptoms Longitudinally Mediate the Effect of Hyperglycemia on Memory Decline in Type 2 Diabetes.

  2023cited by this paper
• Metal mixtures and DNA methylation measures of biological aging in American Indian populations

  2023cited by this paper
• Clinical biomarker-based biological aging and risk of cancer in the UK Biobank

  2023cited by this paper
• Long-term effect of styrene and ethylbenzene exposure on fasting plasma glucose: A gene-environment interaction study.

  2023cited by this paper
• Heavy metal risk of disposable food containers on human health.

  2023cited by this paper
• The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis

  2022cited by this paper
• Associations between multiple metals exposure and biological aging: Evidence from the Dongfeng-Tongji cohort.

  2022cited by this paper
• Associations between household solid fuel use and activities of daily living trajectories: A nationwide longitudinal study of middle and older adults in China.

  2022cited by this paper
• Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis

  2022cited by this paper
• Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults

  2022cited by this paper
• Zinc in soil reflecting the intensive coal mining activities: Evidence from stable zinc isotopes analysis.

  2022cited by this paper
• Senescent chondrogenic progenitor cells derived from articular cartilage of knee osteoarthritis patients contributes to senescence-associated secretory phenotype via release of IL-6 and IL-8.

  2022cited by this paper
• The aging lung: Physiology, disease, and immunity

  2021cited by this paper
• The impact of zinc and folic acid supplementation on sperm DNA methylation: results from the folic acid and zinc supplementation randomized clinical trial (FAZST).

  2021cited by this paper
• Ultrafine particles, particle components and lung function at age 16 years: The PIAMA birth cohort study.

  2021cited by this paper
• Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals

  2021cited by this paper
• Genetic associations for two biological age measures point to distinct aging phenotypes

  2021cited by this paper
• DNA methylation-based age clocks: from age prediction to age reversion.

  2021cited by this paper
• Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin

  2021cited by this paper
• A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration.

  2021cited by this paper
• Depression as a mediator between frequent nightmares and non-suicidal self-injury among adolescents: a 3-wave longitudinal model.

  2020cited by this paper
• Zinc supplementation ameliorates lung injury by reducing neutrophil recruitment and activity

  2020cited by this paper
• Genetic susceptibility to asthma increases the vulnerability to indoor air pollution

  2020cited by this paper
• Cross-sectional and longitudinal associations between urinary zinc and lung function among urban adults in China

  2020cited by this paper
• Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

  2020cited by this paper
• The associations of multiple metals mixture with accelerated DNA methylation aging.

  2020cited by this paper
• Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.

  2019cited by this paper
• Interaction of Glutathione S‐Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents

  2019cited by this paper
• Urinary metals and metal mixtures in midlife women: The Study of Women's Health Across the Nation (SWAN).

  2019cited by this paper
• An epigenetic biomarker of aging for lifespan and healthspan

  2018cited by this paper
• Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies.

  2018cited by this paper
• Environmental and public health related risk of veterinary zinc in pig production - Using Denmark as an example.

  2018cited by this paper
• Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF‐κB activation

  2018cited by this paper
• Maternal dietary antioxidant intake in pregnancy and childhood respiratory and atopic outcomes: birth cohort study

  2018cited by this paper
• Zinc regulates Nox1 expression through a NF‐&kgr;B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

  2017cited by this paper
• Biological Age Predictors

  2017cited by this paper
• Chelation of hippocampal zinc enhances long‐term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory

  2016cited by this paper
• Menopause accelerates biological aging

  2016cited by this paper
• Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions

  2015cited by this paper
• The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort

  2014cited by this paper
• Aging, cellular senescence, and cancer.

  2013cited by this paper
• Gender and age differences in mixed metal exposure and urinary excretion.

  2011cited by this paper
• Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder

  2010cited by this paper
• Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

  2009cited by this paper
• Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells.

  2008cited by this paper
• Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.

  2006cited by this paper
• A new approach to the concept and computation of biological age.

  2006cited by this paper
• AIR POLLUTION AND LUNG FUNCTION AMONG SUSCEPTIBLE ADULT SUBJECTS: A PANEL STUDY

  2004cited by this paper
• Importance of interleukin-8 in the development of reexpansion lung injury in rabbits.

  2000cited by this paper
• Standardization of Spirometry, 1994 Update. American Thoracic Society.

  1995cited by this paper
• Edinburgh Research Explorer Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

  year unknowncited by this paper

• No citing papers are available for this paper.