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3D printing of acetaminophen suppository and its quality and pharmacokinetic evaluation

Ming Chen,Meitao Duan,Jungang Ren,Xiuhong Lin,Zheng Chen,Junfang Ke,Huayun Ye,Zhiqiang Zhang,Chen Wang

Published 2025 in 3D Printing in Medicine

ABSTRACT

Acetaminophen is a widely used antipyretic and analgesic treatment. Becuase oral administration poses a risk of acute liver failure, researchers are exploring alternative routes of administration using 3D printing. This study reports a novel 3D-printed suppository using hot melt extrusion and melt deposition molding technologies. Through excipients screening, process screening and 3D printing, the production can be filtered to the most optimal state. After successfully prepared 3D printed acetaminophen suppository, the suppository’s performance and pharmacokinetics profile were also evaluated. Prepared 3D printed suppository has a complete appearance, smooth interlayer stacking and qualified content determination with over 90% within 6 hours’ in vitro release trend. The 3D printing acetaminophen suppository also has better release and distribution curve than the marketing acetaminophen suppository. The obtained product has a complete appearance, smooth interlayer stacking and stable drug active molecules (API) at the test temperature. Melt deposition molding technologies offers a viable option for the 3D printing preparation of acetaminophen suppository.

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