Sex-type specification and meristem development in fern gametophytes

Sex determination, involving the physiological and morphological separation of male and female gamete-producing structures, promotes outcrossing and helps maintain genetic diversity in land plants. In homosporous ferns, which lack sex chromosomes, sex determination is specified during the gametophyte stage and is regulated by intergametophytic signaling mediated by the pheromone antheridiogen. Ceratopteris richardii has long served as a model for dissecting the molecular and cellular mechanisms underlying fern sex determination and associated meristem development in fern gametophytes, and in recent years, important new progress has been achieved. In this review, we summarize recent findings that uncover key environmental and molecular factors influencing antheridiogen responses and highlight the cellular basis of sex-type specification and the initiation and maintenance of meristems in Ceratopteris gametophytes. We also discuss emerging directions in the field, emphasizing the importance of spatial expression dynamics and interacting regulatory networks in fern sexual differentiation. Future advances will likely be driven by integrating genetic tools, multi-omics platforms, and quantitative live-imaging approaches, offering a more comprehensive view of the regulatory logic underlying sex determination and meristem development in ferns.

• Publication year

  2025

• Venue

  Discover Developmental Biology

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s00427-025-00728-6PMID 41306315PMCID 12645819
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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