Assessment of chemotherapy-induced DNA damage in peripheral blood leukocytes of cancer patients using the alkaline comet assay.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Teratogenesis, carcinogenesis, and mutagenesis (Print)

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/TCM.1035PMID 11754384
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Application of the alkaline comet assay in human biomonitoring for genotoxicity: a study on Croatian medical personnel handling antineoplastic drugs.

  2001cited by this paper
• Analysis of chromate-induced DNA-protein crosslinks with the comet assay.

  2000cited by this paper
• Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families.

  2000cited by this paper
• Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing

  2000cited by this paper
• Molecular epidemiology studies on occupational and environmental exposure to mutagens and carcinogens, 1997-1999.

  2000cited by this paper
• Pesticide-induced primary DNA damage in peripheral blood leukocytes of farm workers evaluated by the computerized 'comet' assay.

  2000cited by this paper
• Application of cytogenetic endpoints and Comet assay on human lymphocytes treated with vincristine in vitro.

  2000cited by this paper
• DNA damage and repair in individual cells: applications of the comet assay in radiobiology.

  1999cited by this paper
• Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxins.

  1999cited by this paper
• Lack of adverse effect of smoking habit on DNA strand breakage and base damage, as revealed by the alkaline comet assay.

  1999cited by this paper
• The comet assay in clinical practice.

  1999cited by this paper
• Comet assay for nuclear DNA damage.

  1999cited by this paper
• Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay.

  1999cited by this paper
• Common fragile site expression and genetic predisposition to breast cancer.

  1998cited by this paper
• Single cell gel electrophoresis assay: sensitivity of peripheral white blood cells in human population studies.

  1998cited by this paper
• Human effect monitoring in cases of occupational exposure to antineoplastic drugs: a method comparison.

  1998cited by this paper
• Induction of apoptosis by bleomycin in resting and cycling human lymphocytes.

  1998cited by this paper
• Detection of DNA lesions induced by chemical mutagens by the single cell electrophoresis (Comet) assay. 1. Relationship between the onset of DNA damage and the characteristics of mutagens.

  1998cited by this paper
• Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies

  1998cited by this paper
• Comet assay in human biomonitoring studies: Reliability, validation, and applications

  1997cited by this paper
• Second malignant neoplasms occuring in survivors of osteosarcoma

  1997cited by this paper
• Alkaline single-cell gel electrophoresis and human biomonitoring for genotoxicity: a pilot study on breast cancer patients undergoing chemotherapy including cyclophosphamide.

  1997cited by this paper
• Alkaline single cell gel electrophoresis of DNA fragments in biomonitoring for genotoxicity: an introductory study on healthy human volunteers

  1997cited by this paper
• Evaluation of the Porphyrinogenic Risk of Antineoplastics

  1997cited by this paper
• Detection of DNA lesions induced by chemical mutagens by the single cell gel electrophoresis (Comet) assay. 1. Relationship between the onset of DNA damage and the characteristics of mutagens.

  1997cited by this paper
• Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay.

  1997cited by this paper
• Treatment-related leukemia in breast cancer patients treated with fluorouracil-doxorubicin-cyclophosphamide combination adjuvant chemotherapy: the University of Texas M.D. Anderson Cancer Center experience.

  1996cited by this paper
• Significance of lymphocytic sister chromatid exchange frequencies in ovarian cancer patients.

  1996cited by this paper
• Analysis of DNA alkylation damage and repair in mammalian cells by the comet assay.

  1996cited by this paper
• Monitoring occupational exposure to cancer chemotherapy drugs.

  1996cited by this paper
• Chemical degradation of wastes of antineoplastic agents: cyclophosphamide, ifosfamide and melphalan

  1996cited by this paper
• The comet assay: a comprehensive review.

  1995cited by this paper
• Application of biological markers in cancer environmental epidemiology.

  1995cited by this paper
• The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay.

  1995cited by this paper
• Sizing highly fragmented DNA in individual apoptotic cells using the comet assay and a DNA crosslinking agent.

  1995cited by this paper
• DNA‐damaging effect of cyclophosphamide on human blood cells in vivo and in vitro studied with the single‐cell gel test (comet assay)

  1995cited by this paper
• Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks.

  1995cited by this paper
• Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects.

  1994cited by this paper
• Sister-chromatid exchanges, chromosomal aberrations and cytotoxicity produced by topoisomerase II-targeted drugs in sensitive (A2780) and resistant (A2780-DX3) human ovarian cancer cells: correlations with the formation of DNA double-strand breaks.

  1994cited by this paper
• Consequences of the resistance to drug-induced topoisomerase II-mediated DNA cleavage.

  1993cited by this paper
• Chemistry of drug-induced DNA lesions

  1993cited by this paper
• Cytogenetic studies in lymphocytes of patients with rectal cancer.

  1993cited by this paper
• Chemistry of drug-induced DNA lesions.

  1993cited by this paper
• In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

  1993cited by this paper
• Mutagenesis after cancer therapy.

  1993cited by this paper
• Synergism and antagonism in cancer chemotherapy

  1992cited by this paper
• Modulation of fluorouracil by N-(phosphonacetyl)-L-asparate: a review.

  1992cited by this paper
• High-dose combination alkylating agents with autologous bone-marrow support in patients with breast cancer: preliminary assessment of DNA damage in individual peripheral blood lymphocytes using the single cell gel electrophoresis assay.

  1992cited by this paper
• The origins of DNA breaks: a consequence of DNA damage, DNA repair, or apoptosis?

  1992cited by this paper
• Cisplatin-DNA damage and repair in peripheral blood leukocytes in vivo and in vitro.

  1992cited by this paper
• Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. II. Alteration of DNA repair and chromosome radiosensitivity.

  1990cited by this paper
• A simple technique for quantitation of low levels of DNA damage in individual cells.

  1988cited by this paper
• International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques.

  1988cited by this paper
• Risk of leukaemia in ovarian tumour and breast cancer patients following treatment by cyclophosphamide.

  1987cited by this paper
• Melphalan may be a more potent leukemogen than cyclophosphamide.

  1986cited by this paper
• Problems in the estimation of mutation rates and in the detection of induced mutations in man.

  1975cited by this paper

• Evaluating DNA Damage in Peripheral Blood Lymphocytes: A Promising Biomarker for Diagnosis, Prognosis and Treatment Monitoring in Colorectal Cancer.

  2026cites this paper
• DNA damage of peripheral blood lymphocytes as a dual biomarker: Diagnostic and treatment response in woman breast cancer patients

  2025cites this paper
• Assessment of metronomic chemotherapy–induced DNA damage in peripheral blood leukocytes from canine mammary cancer patients using the alkaline comet assay

  2024cites this paper
• DNA base oxidation in relation to TNM stages and chemotherapy treatment in colorectal cancer patients 2-9 months post-surgery.

  2023cites this paper
• BRCA1 VUS: A functional analysis to differentiate pathogenic from benign variants identified in clinical diagnostic panels for breast cancer

  2023cites this paper
• PERIPHERAL BLOOD MONONUCLEAR DNA DAMAGE IDENTIFIED BY THE «СOMET» METHOD, AS A POSSIBLE INDICATOR OF SENSITIVITY OF MELANOMA TO IMMUNOTHERAPY WITH NIVOLUMAB

  2021cites this paper
• Antitumor, Immunomodulatory and Antiangiogenic Efficacy of Medicinal Mushroom Extract Mixtures in Advanced Colorectal Cancer Animal Model

  2020cites this paper
• Deep learning method for comet segmentation and comet assay image analysis

  2020cites this paper
• Changes in the levels of comet parameters before and after fluoxetine therapy in major depression patients

  2020cites this paper
• Two phase I, pharmacokinetic, and pharmacodynamic studies of DFP-10917, a novel nucleoside analog with 14-day and 7-day continuous infusion schedules

  2019cites this paper
• Genotoxicity assessment of a selected cytostatic drug mixture in human lymphocytes: A study based on concentrations relevant for occupational exposure

  2018cites this paper
• DNA damage in blood cells in relation to chemotherapy and nutritional status in colorectal cancer patients-A pilot study.

  2018cites this paper
• Micronuclei in peripheral blood lymphocytes of patients with of the gastrointestinal cancer

  2017cites this paper
• Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

  2017cites this paper
• Cytogenetic Analysis on the Yields of Chromosomal Aberrations Induced by the Scattered Doses of ó-Radiation

  2016cites this paper
• CometQ: An automated tool for the detection and quantification of DNA damage using comet assay image analysis

  2016cites this paper
• Combined cyto/genotoxic activity of a selected antineoplastic drug mixture in human circulating blood cells.

  2016cites this paper
• A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor

  2015cites this paper
• [The comet assay as a method of identifying chromosomes instability].

  2014cites this paper
• Prediction of individual response to anticancer therapy: historical and future perspectives

  2014cites this paper
• DNA crosslinks, DNA damage and repair in peripheral blood lymphocytes of non-small cell lung cancer patients treated with platinum derivatives.

  2014cites this paper
• [Use of comet assay for the risk assessment of oil- and chemical-industry workers].

  2014cites this paper
• Relationship between genotoxic effects of breast cancer treatments and patient basal DNA integrity.

  2014cites this paper
• Genetic Alterations in Iraqi Leukaemia Patients as Indicator for Polluted Environment

  2014cites this paper
• Comet assay alkalmazása olaj-és vegyipari exponált dolgozók kockázatbecslésében

  2014cites this paper
• Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the comet assay as a possible predictive factor.

  2013influential citation
• A comparison of the in vitro Genotoxicity of Anticancer Drugs Melphalan and Mitoxantrone

  2013cites this paper
• Relationships between cisplatin-induced adducts and DNA strand-breaks, mutation and recombination in vivo in somatic cells of Drosophila melanogaster, under different conditions of nucleotide excision repair.

  2012cites this paper
• Tumor Growth Inhibitory Effect of Juglone and Its Radiation Sensitizing Potential

  2012cites this paper
• Establishing a genotoxic predictive test of toxicities and response to irinotecan chemotherapy in metastatic colorectal cancer

  2012cites this paper
• Selenium as a Modulator of Efficacy and Toxicity of Chemotherapy and Radiation

  2011cites this paper
• DNA damage and repair in leukocytes of melanoma patients exposed in vitro to cisplatin

  2011cites this paper
• Cytogenetic follow-up in testicular seminoma patients exposed to adjuvant radiotherapy.

  2010cites this paper
• Avaliação in vitro da cisplatina, em linfócitos de pacientes com melanoma cutâneo, por meio de testes citogenéticos

  2010cites this paper
• Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells

  2009cites this paper
• Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: a novel class of anticancer agents.

  2009cites this paper
• Polymorphisms in XRCC5, XRCC6, XRCC7 genes are involved in DNA double-strand breaks（DSBs） repair associated with the risk of acute myeloid leukemia（AML） in Chinese population

  2009cites this paper
• Cytotoxic studies of anti-neoplastic drugs on human lymphocytes – In vitro studies

  2009cites this paper
• Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression

  2008cites this paper
• Potential use of the comet assay in the clinical management of cancer.

  2008cites this paper
• Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers.

  2008cites this paper
• DNA damage in peripheral blood lymphocytes in patients during combined chemotherapy for breast cancer.

  2008cites this paper
• In vivo detection of DNA adducts induced by cisplatin using capillary HPLC–ICP-MS and their correlation with genotoxic damage in Drosophila melanogaster

  2008cites this paper
• Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane

  2008cites this paper
• Evaluation of DNA damage in radiotherapy-treated cancer patients using the alkaline comet assay.

  2007cites this paper
• Application of human lymphocytes for evaluating toxicity of anti-cancer drugs.

  2006cites this paper
• Variation of ATM protein expression in response to irradiation of lymphocytes in lung cancer patients and controls.

  2006cites this paper
• DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy.

  2006cites this paper
• Alkaline comet assay study with breast cancer patients: evaluation of baseline and chemotherapy-induced DNA damage in non-target cells

  2006cites this paper
• Interactions between inhaled anesthetics and cytostatic agents

  2006influential citation
• Transplatin is cytotoxic when photoactivated: enhanced formation of DNA cross-links.

  2006cites this paper
• Comet-assay in combination with PNA-FISH detects mutagen-induced DNA damage and specific repeat sequences in the damaged DNA of transformed cells.

  2005cites this paper
• The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells.

  2005cites this paper
• Genotoxicity of environmental agents assessed by the alkaline comet assay.

  2005cites this paper
• [Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project].

  2005influential citation
• The use of the alkaline comet assay with lymphocytes in human biomonitoring studies.

  2004cites this paper
• DNA damage in peripheral lymphocytes of untreated breast cancer patients.

  2004cites this paper
• DNA Damage in Peripheral Lymphocytes of Untreated Breast Cancer Patients

  2004cites this paper
• DNA damage induced by paclitaxel and DNA repair capability of peripheral blood lymphocytes as evaluated by the alkaline comet assay.

  2004cites this paper
• In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles.

  2004cites this paper
• Measuring the genetic damage in cancer patients during radiotherapy with three genetic end-points.

  2004cites this paper
• Mutant Nbs1 Enhances Cisplatin-Induced DNA Damage and Cytotoxicity in Head and Neck Cancer

  2003cites this paper
• A MULTI-BIOMARKER APPROACH TO STUDY THE GENOTOXIC EFFECTS OF IRINOTECAN ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO

  year unknowncites this paper