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Impact of Quitting Smoking at Diagnosis on Overall Survival in Lung Cancer Patients: A Comprehensive Meta-Analysis

J. M. Lee,Hyo-Weon Suh,Hyeon-Jeong Lee,Miyoung Choi,Ji Soo Kim,Kiheon Lee,Sang-Heon Kim,J. W. Sohn,Ho Joo Yoon,Yu-Jin Paek,Cheol-Min Lee,D. Park

Published 2025 in Cancers

ABSTRACT

Simple Summary Quitting smoking at or around the time of the lung cancer diagnosis is thought to substantially improve survival, yet evidence from diverse studies has been inconsistent. This systemic review was conducted to clarify the survival benefit of quitting smoking at diagnosis. We analyzed 25 studies including 17,584 patients and found that patients who stopped smoking at diagnosis had a 26% lower risk of death compared with those who continued smoking. The survival benefit was observed across both NSCLC and SCLC and was particularly pronounced in early-stage disease. Importantly, active smoking cessation interventions were associated with the greater survival improvement. These findings highlight the critical role of integrating structured smoking cessation programs into lung cancer management and may guide future clinical practice and policy development.

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