Hybrid Nano-Bio Platforms: Synergistic Strategies Combining Probiotic Metabolites and Nanocarriers Against Multidrug-Resistant Pathogens

Multidrug-resistant (MDR) bacterial infections are becoming more common, which is a serious global health concern that calls for innovative antimicrobial approaches that go beyond traditional antibiotic treatments. In order to improve antibacterial efficacy, this review carefully investigates hybrid nano-bio platforms that combine probiotic-derived metabolites with nanoscale delivery technologies in a synergistic manner. Despite having natural antibacterial, antibiofilm, and immunomodulatory properties, probiotic metabolites such as bacteriocins, biosurfactants, organic acids, and reuterin are clinically limited because of their poor stability and lack of targeted administration. By enhancing bioavailability, stability, and permitting controlled, stimuli-responsive release, encapsulation within nanocarriers such polymeric nanoparticles, liposomes, solid lipid nanoparticles, and metallic nanostructures overcomes these difficulties. These hybrid systems restore antibiotic sensitivity and increase pathogen clearance by acting through a variety of antibacterial mechanisms, such as membrane rupture, efflux pump inhibition, biofilm penetration, and immunological modulation. Stimuli-responsive designs maximise therapeutic specificity while reducing off-target toxicity by enabling precise drug release in response to microenvironmental cues such as pH changes or oxidative stress. Translational obstacles still exist despite encouraging preclinical studies showing strong and long-lasting antibacterial activities with excellent biocompatibility characteristics. These include issues with thorough safety evaluations, regulatory classification, and scalable production. The development of adaptive, multifunctional, and safe next-generation antimicrobials that can successfully combat MDR pathogens and stop the global antibiotic resistance crisis is made possible by the interdisciplinary integration of microbial biotechnology and nanomedicine, which is embodied in hybrid nano-bio platforms.

• Publication year

  2025

• Venue

  International Journal of Innovative Science and Research Technology

• Publication date

  2025-11-08

• Fields of study

  Not labeled

• Identifiers
  DOI 10.38124/ijisrt/25nov019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics

  2025cited by this paper
• Advancing drug delivery research: sustainable strategies for innovation and translation

  2025cited by this paper
• Innovative polymer-based therapeutics targeting inflammation for responsive drug delivery in disease treatment

  2025cited by this paper
• Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise

  2025cited by this paper
• Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives

  2024cited by this paper
• Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment

  2024cited by this paper
• Multifunctional nanoparticle-mediated combining therapy for human diseases

  2024cited by this paper
• Recent Advances in Pharmaceutical Design: Unleashing the Potential of Novel Therapeutics.

  2024cited by this paper
• Nano–Bio Interaction and Antibacterial Mechanism of Engineered Metal Nanoparticles: Fundamentals and Current Understanding

  2024cited by this paper
• Advancing Antibiotic-Resistant Microbe Combat: Nanocarrier-Based Systems in Combination Therapy Targeting Quorum Sensing

  2024cited by this paper
• Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

  2024cited by this paper
• Recent advances in endogenous and exogenous stimuli-responsive nanoplatforms for bacterial infection treatment

  2023cited by this paper
• Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer

  2023cited by this paper
• Nanotechnological interventions in bacteriocin formulations – advances, and scope for challenging food spoilage bacteria and drug-resistant foodborne pathogens

  2023cited by this paper
• Use of Plant Extracts, Bee-Derived Products, and Probiotic-Related Applications to Fight Multidrug-Resistant Pathogens in the Post-Antibiotic Era

  2023cited by this paper
• Nanotechnology as a Promising Approach to Combat Multidrug Resistant Bacteria: A Comprehensive Review and Future Perspectives

  2023cited by this paper
• Nano-Formulation Endows Quorum Quenching Enzyme-Antibiotic Hybrids with Improved Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa

  2022cited by this paper
• Nano-biotechnology, an applicable approach for sustainable future

  2022cited by this paper
• Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace

  2022cited by this paper
• Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

  2022cited by this paper
• Current therapeutic interventions combating biofilm-related infections in orthopaedics

  2022cited by this paper
• Membrane Vesicles Derived from Gut Microbiota and Probiotics: Cutting-Edge Therapeutic Approaches for Multidrug-Resistant Superbugs Linked to Neurological Anomalies

  2022cited by this paper
• Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects

  2021cited by this paper
• Stimuli-responsive nanocarriers for bacterial biofilm treatment

  2021cited by this paper
• Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety

  2021cited by this paper
• Antimicrobial Property of Probiotics

  2021cited by this paper
• Bioactive compounds produced by probiotics in food products

  2020cited by this paper
• Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery

  2020cited by this paper
• Nanoencapsulation of bioactive compounds: challenges and perspectives

  2019cited by this paper
• FORMULATION AND EVALUATION OF CONTROLLED RELEASE FLOATING TABLETS OF CEFIXIME USING HYDROPHILIC POLYMERS

  2019cited by this paper
• Complex Responses to Hydrogen Peroxide and Hypochlorous Acid by the Probiotic Bacterium Lactobacillus reuteri

  2019cited by this paper
• Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

  2019cited by this paper
• World Health Organization Report: Current Crisis of Antibiotic Resistance

  2019cited by this paper
• Biochemical Characteristics of Microbial Enzymes and Their Significance from Industrial Perspectives

  2019cited by this paper
• Cytotoxicity of Nanomaterials: Using Nanotoxicology to Address the Safety Concerns of Nanoparticles.

  2018cited by this paper
• Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists

  2018cited by this paper
• Bacteriocin-nanoconjugates as emerging compounds for enhancing antimicrobial activity of bacteriocins

  2017cited by this paper
• Multifunctional soft hybrid bio-platforms based on nano-silver and natural compounds.

  2016cited by this paper
• Bio-nano hybrid materials based on bacteriorhodopsin: Potential applications and future strategies.

  2015cited by this paper
• Advanced Micro-Nano-Bio Systems for Future Targeted Therapies

  2015cited by this paper
• The effects of pH on wound healing, biofilms, and antimicrobial efficacy

  2014cited by this paper
• Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity.

  2014cited by this paper
• Antibiotic resistance-the need for global solutions.

  2013cited by this paper

• No citing papers are available for this paper.