Whole-Exome Sequencing-Based Linkage Analysis of Multiple Myeloma (MM) and Monoclonal Gammopathy of Undetermined Significance (MGUS) Pedigrees

Simple Summary People with relatives who have multiple myeloma or its early condition, monoclonal gammopathy of undetermined significance, face higher risk. Most research has focused on common DNA changes, but these do not explain all inherited risk. We studied 79 families with two or more affected relatives and examined their protein-coding DNA to find regions that are passed down together with disease. We found strong evidence that a stretch of chromosome 6 (q22.33–q24.2) is linked to risk. Within this region, we highlighted 14 rare variants predicted to affect gene function; nine reside in areas that regulate immune cells. This work shows that family-based DNA linkage can uncover risk regions missed by previous approaches and points to new genes and pathways that may help explain—and ultimately predict—risk for multiple myeloma and its precursor.

• Publication year

  2025

• Venue

  Cancers

• Publication date

  2025-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3390/cancers17223611PMID 41300981PMCID 12651453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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