Clinical outcomes of minimally invasive bone grafting integrated with concentrated growth factor for periodontitis.

OBJECTIVE Periodontitis is a prevalent chronic inflammatory disease characterized by progressive destruction of periodontal tissues, with alveolar bone defects posing significant challenges for clinical treatment. This research aimed to ascertain the clinical efficacy of minimally invasive bone grafting combined with concentrated growth factor (CGF) for treating periodontitis. METHODS Seventy-eight patients with periodontitis and bone defects were randomized into the control group (received guided tissue regeneration (GTR) combined with bone grafting treatment) and the test group (received GTR combined with minimally invasive bone grafting and CGF treatment). Postoperative pain at 1 day, 3 days, and 7 days postoperatively, mucosal healing at 7 days postoperatively, probing depth (PD), clinical attachment level (CAL), gingival recession depth (GRD), bleeding index (BI), gingival index (GI), and the alveolar bone defect depth preoperatively and at 6 months postoperatively were compared, changes in implant new bone thickness and density at 3 and 6 months postoperatively were tested by cone-beam computed tomography (CBCT), and implantation success rate and postoperative complications were compared. RESULTS The test group exhibited lower pain scores at 3 and 7 days (P < 0.05), improved mucosal healing (P < 0.05), and superior periodontal indicators (PD, CAL, GRD, BI, GI) at 6 months (P < 0.05). CBCT revealed greater bone thickness/density in the test group (P < 0.05). Complication rates were lower in the test group (P < 0.05), with no significant difference in implantation success (P > 0.05). CONCLUSION Minimally invasive bone grafting combined GTR with CGF improves periodontal conditions in patients with periodontitis complicated by bone defects, achieves good bone regeneration results, and reduces postoperative complications.

• Publication year

  2025

• Venue

  Journal of Stomatology Oral and Maxillofacial Surgery

• Publication date

  2025-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jormas.2025.102645PMID 41223992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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